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Apolipoprotein E

Summary

UniProt ID

P08226

Gene Symbol

Apoe

Organism

Mus musculus (house mouse)

External Links

GlyGen: P08226
PubChem: P08226
The O-GlcNAc Database: P08226

Annotation

Keyword

3D-structure
Chylomicron
Direct protein sequencing
Endosome
Extracellular matrix
Glycoprotein
HDL
Heparin-binding
Lipid transport
Lipid-binding
Oxidation
Phosphoprotein
Reference proteome
Repeat
Signal
VLDL

Gene Ontology (GO)

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GO Term
negative regulation of endothelial cell proliferation
lipid metabolic process
regulation of protein-containing complex assembly
negative regulation of neuron apoptotic process
negative regulation of blood vessel endothelial cell migration
positive regulation of nitric oxide biosynthetic process
positive regulation of endocytosis
positive regulation of lipid biosynthetic process
negative regulation of smooth muscle cell proliferation
artery morphogenesis

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GO Term
extracellular region
extracellular space
nuclear envelope
Golgi apparatus
extracellular matrix
melanosome
dendrite
cell surface
chylomicron
multivesicular body, internal vesicle

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GO Term
signaling receptor binding
lipid transporter activity
heparin binding
enzyme binding
very-low-density lipoprotein particle receptor binding
hydroxyapatite binding
lipoprotein particle binding
low-density lipoprotein particle receptor binding
phosphatidylcholine-sterol O-acyltransferase activator activity
cholesterol transfer activity

Annotation information from UniProt.

Sequence

MKALWAVLLVTLLTGCLAEGEPEVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPIITPVAQENQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Chylomicron assembly	Mus musculus
Chylomicron clearance	Mus musculus
Chylomicron remodeling	Mus musculus
HDL remodeling	Mus musculus
Post-translational protein phosphorylation	Mus musculus
Regulation of IGF Activity by IGFBP	Mus musculus
Retinoid metabolism and transport	Mus musculus
Scavenging by Class A Receptors	Mus musculus