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Apolipoprotein E

Summary

UniProt ID

P08226

Gene Symbol

Apoe

Organism

Mus musculus (house mouse)

External Links

GlyGen: P08226
PubChem: P08226
The O-GlcNAc Database: P08226

Annotation

Keyword

3D-structure
Chylomicron
Direct protein sequencing
Endosome
Extracellular matrix
Glycoprotein
HDL
Heparin-binding
Lipid transport
Lipid-binding
Oxidation
Phosphoprotein
Reference proteome
Repeat
Signal
VLDL

Gene Ontology (GO)

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GO Term
intermediate-density lipoprotein particle clearance
positive regulation of amyloid-beta clearance
negative regulation of long-term synaptic potentiation
negative regulation of amyloid-beta formation
positive regulation of dendritic spine maintenance
positive regulation of phospholipid efflux
regulation of cellular response to very-low-density lipoprotein particle stimulus
negative regulation of amyloid fibril formation
positive regulation of CoA-transferase activity

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GO Term
neuronal cell body
extracellular exosome
glutamatergic synapse
extracellular vesicle
extrinsic component of external side of plasma membrane
cytosol
endosome
endoplasmic reticulum
synaptic cleft
late endosome

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GO Term
signaling receptor binding
lipid transporter activity
heparin binding
enzyme binding
hydroxyapatite binding
lipoprotein particle binding
low-density lipoprotein particle receptor binding
phosphatidylcholine-sterol O-acyltransferase activator activity
cholesterol transfer activity
identical protein binding

Annotation information from UniProt.

Sequence

MKALWAVLLVTLLTGCLAEGEPEVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPIITPVAQENQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Chylomicron assembly	Mus musculus
Chylomicron clearance	Mus musculus
Chylomicron remodeling	Mus musculus
HDL remodeling	Mus musculus
Post-translational protein phosphorylation	Mus musculus
Regulation of IGF Activity by IGFBP	Mus musculus
Retinoid metabolism and transport	Mus musculus
Scavenging by Class A Receptors	Mus musculus