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Transforming growth factor beta-3 proprotein

Summary

UniProt ID

P10600

Gene Symbol

TGFB3

Organism

Homo sapiens (human)

External Links

GlyConnect

1837

GlyGen

P10600

PubChem

P10600

The Human Metabolome Database

HMDBP14474

The O-GlcNAc Database

P10600

Annotation

Keyword

3D-structure
Alternative splicing
Cardiomyopathy
Cleavage on pair of basic residues
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Growth factor
Methylation
Mitogen
Reference proteome
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 39 in total

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GO Term
positive regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II
response to hypoxia
uterine wall breakdown
negative regulation of vascular associated smooth muscle cell proliferation
transforming growth factor beta receptor signaling pathway
salivary gland morphogenesis
positive regulation of epithelial to mesenchymal transition
negative regulation of macrophage cytokine production
negative regulation of transforming growth factor beta receptor signaling pathway

Displaying **all 9** entries
GO Term
platelet alpha granule lumen
cell surface
T-tubule
extracellular region
extracellular space
plasma membrane
neuronal cell body
intracellular membrane-bounded organelle
collagen-containing extracellular matrix

Displaying **all 8** entries
GO Term
type II transforming growth factor beta receptor binding
cytokine activity
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
identical protein binding
protein-containing complex binding
transforming growth factor beta binding

Annotation information from UniProt.

Sequence

MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	GlyTouCan ID	Source
60			GlyGen
74	N-linked (GlcNAc...) asparagine	G45395BF G47702MW G02886BB G62765YT	UniProt GlyGen
128		G49108TO	The O-GlcNAc Database
135	N-linked (GlcNAc...) asparagine	G84452RH G70101JE G80920RR G62765YT G64527OM	UniProt GlyGen GlyConnect
142	N-linked (GlcNAc...) asparagine		UniProt GlyGen
357		G57321FI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
ECM proteoglycans	Homo sapiens
Molecules associated with elastic fibres	Homo sapiens
Platelet degranulation	Homo sapiens
TGF-beta receptor signaling activates SMADs	Homo sapiens