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Complement component C7

Summary

UniProt ID: P10643
Gene Symbol: C7
Gene ID: 730
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011472

GlyConnect

Complement component c7

GlyGen

P10643

PubChem

P10643

Re-Glyco

P10643

Annotation

Keyword: 3D-structure Complement alternate pathway Direct protein sequencing Disease variant Disulfide bond EGF-like domain Glycoprotein Membrane attack complex Proteomics identification Reference proteome Repeat Secreted Signal Sushi Target cell membrane

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
complement activation	TAS	PMID
complement activation	IDA	PMID PMID PMID PMID PMID PMID
complement activation	IBA	GO_REF
complement activation, alternative pathway
complement activation, classical pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

cellular process [inference]

cell killing [inference]

killing of cells of another organism

transmembrane transport

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
extracellular region	EXP	PMID
extracellular region	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
extracellular region	IEA	GO_REF
membrane attack complex	TAS	PMID
membrane attack complex	IDA	PMID PMID PMID PMID PMID PMID PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

other organism cell membrane

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKVISLFILVGFIGEFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEGCGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKPPPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKINNDFNYEFYNSTWSYVKHTSTEHTSSSRKRSFFRSSSSSSRSYTSHTNEIHKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSSHGCKELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYELVKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGGGRSCVGETTESTQCEDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVGKNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVGEKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSRCVCKMPYECGPSLDVCAQDERSKRILPLTVCKMHVLHCQGRNYTLTGRDSCTLPASAEKACGACPLWGKCDAESSKCVCREASECEEEGFSICVEVNGKEQTMSECEAGALRCRGQSISVTSIRPCAAETQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
36	C-linked (Man) tryptophan	10551839		UniProt GlyGen
202	N-linked (GlcNAc...) asparagine	14760718 16335952 23090970 29741879 37074911	G00912UN G15664MX G24528MX G51653BI G83460ZZ G92406TI G41840AI G01650EU G80920RR G37399XV G62765YT G05049YU G31852PQ G23719VF G41247ZX G02815KT G06110VR G92050GC	UniProt GlyGen GlyConnect
503	C-linked (Man) tryptophan; partial	10551839		UniProt GlyGen
506	C-linked (Man) tryptophan; partial	10551839		UniProt GlyGen
509	C-linked (Man) tryptophan; partial	10551839		UniProt GlyGen
688		28035807	G57321FI	GlyGen
692		28035807	G57321FI	GlyGen
696	O-linked (GalNAc...) threonine	22171320	G29931IJ G43417UB	UniProt GlyGen GlyConnect
754	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490 23090970 29671580 37074911	G57776ZS G90382BL G79666IR G45395BF G43223CG G08918WF G00912UN G48414YA G61256FT G76295SF G27058EU G83460ZZ G41071NU G80920RR G90659AW G62765YT G47644PP G05049YU G31852PQ G11314AS G41247ZX G36379GD G02815KT	GlycoProtDB UniProt GlyGen GlyConnect