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T-cell-specific surface glycoprotein CD28

Summary

UniProt ID

P10747

Gene Symbol

CD28

Organism

Homo sapiens (human)

External Links

GlyGen: P10747
PubChem: P10747
RaftProt: P10747

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 28 in total

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GO Term
positive regulation of cytokine production
humoral immune response
cell surface receptor signaling pathway
positive regulation of gene expression
negative regulation of gene expression
regulation of regulatory T cell differentiation
positive regulation of translation
positive regulation of mitotic nuclear division
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 6** entries
GO Term
plasma membrane
protein complex involved in cell adhesion
cytosol
immunological synapse
external side of plasma membrane
cell surface

Displaying **all 4** entries
GO Term
protease binding
protein kinase binding
identical protein binding
coreceptor activity

Annotation information from UniProt.

Sequence

MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
37	N-linked (GlcNAc...) asparagine	15696168		UniProt GlyGen
71	N-linked (GlcNAc...) asparagine	19349973		UniProt GlyGen
92	N-linked (GlcNAc...) asparagine			UniProt GlyGen
105	N-linked (GlcNAc...) asparagine	15696168		UniProt GlyGen
129	N-linked (GlcNAc...) asparagine	19349973	G27058EU G59626AS G31852PQ G41247ZX	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
CD28 co-stimulation	Homo sapiens
CD28 dependent PI3K/Akt signaling	Homo sapiens
CD28 dependent Vav1 pathway	Homo sapiens
Constitutive Signaling by Aberrant PI3K in Cancer	Homo sapiens
Nef mediated downregulation of CD28 cell surface expression	Homo sapiens
PI3K/AKT Signaling	Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Homo sapiens