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Clusterin

Summary

UniProt ID

P10909

Gene Symbol

CLU
APOJ
CLI
KUB1

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011478

GlyConnect

GlyGen

P10909

PubChem

P10909

The O-GlcNAc Database

P10909

RaftProt

P10909

O-GlcNAcAtlas

P10909

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Chaperone
Complement pathway
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Microsome
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Secreted
Signal
Ubl conjugation

Gene Ontology (GO)

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GO Term
immune complex clearance
positive regulation of NF-kappaB transcription factor activity
chaperone-mediated protein complex assembly
regulation of amyloid-beta clearance
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of amyloid-beta formation
positive regulation of neurofibrillary tangle assembly
negative regulation of response to endoplasmic reticulum stress
positive regulation of amyloid fibril formation
positive regulation of ubiquitin-dependent protein catabolic process

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GO Term
Golgi apparatus
cytosol
cell surface
perinuclear region of cytoplasm
extracellular region
extracellular space
nucleus
cytoplasm
mitochondrion
mitochondrial inner membrane

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GO Term
tau protein binding
protein carrier chaperone
amyloid-beta binding
ubiquitin protein ligase binding
protein-containing complex binding
receptor ligand activity
low-density lipoprotein particle receptor binding
protein-folding chaperone binding
misfolded protein binding
signaling receptor binding

Annotation information from UniProt.

Sequence

MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
86	N-linked (GlcNAc...) (complex) asparagine	1551440 16335952 19139490 19159218 9336835	G95678HJ G67506FN G50427EO G56518TU G78811TO G05962QB G64394MX G54740VA G91158SA G15169WU G70232NH G94917XT G57888GL G70888PK G39689FZ G06247RL G47518TP G35541EV G34617SM G93718GY G37881RL G77582RK G20312EM G80075MS G11629QQ G57776ZS G16125XL G29545VG G68490OW G99668VU G86234IN G26271XI G86795LJ G86880BF G27947YN G52527GH G90382BL G30970QQ G80479JV G90093AU G85282JO G24954UD G87123QX G96577RX G79666IR G81263BG G98611JV G75607BQ G34989PA G81198YO G47012YE G51413EV G08146BT G22310AV G45395BF G07246CJ G66163OV G40926MX G59536GA G77459ND G22625SJ G02030ZB G43223CG G95977AE G54612UD G26330YA G93683YO G08918WF G71146HJ G75983OB G00912UN G42358LZ G48414YA G27915IV G61256FT G70441OD G72797UR G87661QW G76295SF G04657PL G25451PN G27058EU G45495MK G84452RH G24528MX G39619TI G43769HG G83460ZZ G70223PD G41071NU G07755XJ G42962KI G44215PV G70619PT G06356OH G37868ZX G59626AS G08290VR G70101JE G80920RR G01485JJ G42124LM G23863VK G57818FI G90659AW G64409MC G62765YT G64527OM G47644PP G95177YH G10486CT G05049YU G85269DF G95865ZB G05724UK G31852PQ G23719VF G11314AS G41247ZX G02815KT G37995HC	GlycoProtDB UniProt GlyGen GlyConnect
103	N-linked (GlcNAc...) asparagine	1551440 16335952 19159218 2721499 9336835	G56770VP G30221QT G81637OR G50856PC G99679NM G56518TU G60967DT G05962QB G64394MX G13694XX G30740WO G54740VA G78649WQ G45526EA G12341GU G76417NN G15169WU G70232NH G94917XT G57888GL G69521XL G14547CB G81124ET G70888PK G92081HT G03644CB G06247RL G47518TP G93718GY G75568BH G77582RK G20312EM G80075MS G11629QQ G57776ZS G16125XL G41882MT G31596VW G68490OW G99668VU G86234IN G60834IK G86795LJ G86880BF G27947YN G52527GH G28622IK G90382BL G91473PK G24954UD G87123QX G79666IR G81263BG G65019XG G92135MA G34989PA G81198YO G40834TG G43669FQ G51413EV G22310AV G45395BF G88374WZ G07246CJ G04672QB G40926MX G59536GA G14972EH G22625SJ G02030ZB G43223CG G58954YZ G37412TK G31986NC G26330YA G10846ZT G40574BA G82830MN G78787DI G00273SJ G08918WF G47737VJ G71146HJ G75983OB G00912UN G48414YA G49906RN G58087IP G11911BT G70441OD G17208MA G63381RX G72667IM G46691LC G80223IX G25418HZ G04657PL G25451PN G27058EU G45495MK G84452RH G32332VU G43769HG G51640FO G70418MS G24835MQ G72747WU G70619PT G06356OH G59626AS G47448YK G08290VR G25079LO G70101JE G80920RR G50757KG G12313PD G82463GQ G64527OM G11870QZ G10256JP G10486CT G55383ZG G05724UK G39188ZX G94854LT G06110VR G74724QE G84225JN	GlycoProtDB UniProt GlyGen GlyConnect
145	N-linked (GlcNAc...) asparagine	1551440 16335952 19159218 2721499 9336835	G53075ES G11115RO G50856PC G99679NM G56518TU G05962QB G12341GU G70232NH G14547CB G81124ET G70888PK G03644CB G06247RL G47518TP G80075MS G57776ZS G86795LJ G86880BF G27947YN G20528HD G63980BQ G04854VP G94470IW G40834TG G43669FQ G45395BF G07246CJ G59536GA G43223CG G58954YZ G37412TK G31986NC G10846ZT G40574BA G82830MN G00273SJ G08918WF G00912UN G48414YA G49906RN G58087IP G04657PL G27058EU G83460ZZ G60033FS G41071NU G60923RB G70619PT G59626AS G46503DX G25079LO G80920RR G42124LM G83633GK G62765YT	GlycoProtDB UniProt GlyGen GlyConnect
155				GlyGen
199			G57321FI	GlyGen
210			G57321FI	GlyGen
239				GlyGen
291	N-linked (GlcNAc...) asparagine	1551440 16335952 18780401 2721499 9336835	G37818NZ G37881RL G85144OK G86795LJ G27947YN G04854VP G94470IW G79666IR G81263BG G51413EV G08146BT G22310AV G45395BF G66163OV G40926MX G59536GA G77459ND G26330YA G71146HJ G75983OB G00912UN G48414YA G72797UR G76295SF G08293MJ G27058EU G45495MK G84452RH G83460ZZ G20425TQ G60033FS G62837OZ G41071NU G42962KI G44215PV G06356OH G37868ZX G59626AS G01650EU G70101JE G80920RR G23863VK G57818FI G90659AW G45504EY G37399XV G62765YT G64527OM G10486CT G22140GZ G50045TK G46687AB G61937QU G95865ZB G57776ZU G02815KT G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
354	N-linked (GlcNAc...) asparagine	12754519 14760718 1551440 16335952 19159218 9336835	G56770VP G99679NM G36003IU G56518TU G78649WQ G12341GU G15169WU G70232NH G69521XL G14547CB G81124ET G70888PK G92081HT G06247RL G47518TP G20312EM G80075MS G11629QQ G57776ZS G68490OW G75418YA G99668VU G86880BF G27947YN G52527GH G90382BL G80479JV G85282JO G24954UD G63980BQ G04854VP G94470IW G96577RX G79666IR G81263BG G86752LQ G98611JV G34989PA G81198YO G40834TG G02528FI G43669FQ G45395BF G07246CJ G04672QB G10819WX G40926MX G43223CG G58954YZ G31986NC G26330YA G40574BA G82830MN G00273SJ G08918WF G71146HJ G75983OB G00912UN G48414YA G49906RN G78790NZ G27915IV G28096RS G56284ZY G44211QA G70441OD G70822IO G87661QW G83646BJ G76295SF G46691LC G80223IX G25418HZ G27126ED G27058EU G45495MK G84452RH G83460ZZ G51640FO G35235RT G82592ZH G60033FS G41071NU G70418MS G24835MQ G72747WU G44215PV G70619PT G06356OH G59626AS G47448YK G08290VR G92406TI G46503DX G01650EU G48584BU G70101JE G80920RR G63041LO G50757KG G65184UU G03382KH G42124LM G02886BB G90659AW G74430RZ G59924QI G37399XV G62765YT G64527OM G47644PP G10256JP G10486CT G05049YU G46687AB G28541PG G55383ZG G95865ZB G31852PQ G49874UX G39446WN G22572EH G39188ZX G57776ZU G94854LT G02815KT G06110VR G00406II G74724QE G28681TP G72197KC G84225JN G98129XB	GlycoProtDB UniProt GlyGen GlyConnect
374	N-linked (GlcNAc...) (complex) asparagine	14760718 1551440 16263699 16335952 16740002 18780401 19139490 19159218 19838169 9336835	G13910DJ G53075ES G69834CE G79635DB G11115RO G89827JR G72886NH G39595FH G81637OR G07810QS G71463BG G50427EO G81128KB G82443XX G55412XP G56518TU G52890YB G78811TO G19972YZ G73918EY G05962QB G30740WO G54740VA G78649WQ G91158SA G12341GU G76417NN G15169WU G70232NH G94917XT G22589VJ G79286RS G37818NZ G57888GL G69521XL G14547CB G81124ET G70888PK G92081HT G31544HA G39689FZ G33791AF G06247RL G47518TP G34617SM G77582RK G04784US G20312EM G80075MS G11629QQ G57776ZS G85144OK G16125XL G29545VG G31596VW G68490OW G57220OY G46823ME G87875QF G99668VU G26271XI G60834IK G03596YS G86795LJ G86880BF G27947YN G52527GH G90382BL G91473PK G80479JV G02315DX G20528HD G24954UD G04854VP G94470IW G41126SR G87123QX G96577RX G79666IR G81263BG G65019XG G92135MA G34989PA G81198YO G40834TG G86500WE G47012YE G51413EV G08146BT G22310AV G45395BF G88374WZ G59324HL G07246CJ G85554PZ G02628JF G66163OV G66933CM G40926MX G59536GA G14972EH G22625SJ G02030ZB G43223CG G96416FQ G58954YZ G95977AE G37412TK G54612UD G26330YA G10846ZT G40574BA G82830MN G78787DI G00273SJ G83229XP G08918WF G47737VJ G71146HJ G75983OB G00912UN G42358LZ G48414YA G78790NZ G27915IV G11911BT G99966GV G56284ZY G08110WX G61256FT G38398KX G44211QA G70441OD G72797UR G78644BR G70822IO G87661QW G66760KM G17208MA G63381RX G72667IM G76295SF G46691LC G04657PL G25451PN G87051GH G08293MJ G27058EU G45495MK G84452RH G32332VU G37509XX G51640FO G82592ZH G41071NU G91636VS G07755XJ G70418MS G72747WU G42962KI G44215PV G60923RB G70619PT G06356OH G37868ZX G59626AS G47448YK G08290VR G14994KB G70101JE G80920RR G01485JJ G50757KG G42124LM G23863VK G31118FR G57818FI G83555HU G90659AW G74430RZ G45504EY G80333GO G12313PD G62765YT G64527OM G62894KT G11870QZ G10256JP G95177YH G10486CT G22140GZ G50045TK G05049YU G72735IY G55383ZG G85269DF G92597CK G95865ZB G05724UK G31852PQ G23719VF G49874UX G11314AS G29880MM G22572EH G39188ZX G41247ZX G57776ZU G94854LT G02815KT G06110VR G57317CE G74724QE G28681TP G54010QB G72197KC	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Antimicrobial peptides	Homo sapiens
Platelet degranulation	Homo sapiens
Regulation of Complement cascade	Homo sapiens
Terminal pathway of complement	Homo sapiens

Human Protein Atlas

ENSG00000120885

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements