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Glycan Structure Repository
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Glycoconjugate Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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Guidelines
MIRAGE
Growth hormone receptor
Summary
- UniProt ID
- P10912
- Gene Symbol
-
- GHR
- Gene ID
- 2690
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Dwarfism
- Endocytosis
- Glycoprotein
- Phosphoprotein
- Proteomics identification
- Receptor
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasmic ribonucleoprotein granule |
| extracellular region |
| extracellular space |
| plasma membrane |
| membrane |
| neuronal cell body |
| receptor complex |
| cytosol |
| external side of plasma membrane |
| cell surface |
| GO Term |
|---|
| hormone-mediated signaling pathway |
| taurine metabolic process |
| response to food |
| positive regulation of MAP kinase activity |
| positive regulation of receptor signaling pathway via JAK-STAT |
| GO Term |
|---|
| lipid binding |
| growth factor binding |
| protein kinase binding |
| protein phosphatase binding |
| cytokine binding |
| SH2 domain binding |
| identical protein binding |
| protein homodimerization activity |
| peptide hormone binding |
| proline-rich region binding |
Sequence
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 30 |
|
|||
| 32 |
|
|||
| 46 | N-linked (GlcNAc...) asparagine |
|
||
| 115 | N-linked (GlcNAc...) asparagine |
|
||
| 156 | N-linked (GlcNAc...) asparagine |
|
||
| 161 | N-linked (GlcNAc...) asparagine |
|
||
| 200 | N-linked (GlcNAc...) asparagine |
|
||
| 461 |
|
|
G43417UB
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Growth hormone receptor signaling | Homo sapiens |
| Prolactin receptor signaling | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060870 | isolated growth hormone deficiency | |
| DOID:13810 | familial hypercholesterolemia | |
| DOID:5353 | colonic disease | |
| DOID:8398 | osteoarthritis | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9521 | Laron syndrome |
