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Prosaposin

Summary

UniProt ID: P10960
Gene Symbol: Psap Sgp1
Gene ID: 25524
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: P10960
Re-Glyco: P10960

Annotation

Keyword: Direct protein sequencing Disulfide bond Glycoprotein Lysosome Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	Reference
NK T cell differentiation	ISO	GO_REF
corneocyte development	ISO	GO_REF
obsolete membrane lipid metabolic process
glycolipid metabolic process	ISO	GO_REF
sphingolipid metabolic process	ISO	GO_REF

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

ceramide catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

galactolipid metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative catabolic process [inference]

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

glucosylceramide metabolic process

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

galactolipid metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide catabolic process

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycolipid catabolic process [inference]

galactolipid catabolic process [inference]

galactosylceramide catabolic process

glycosphingolipid catabolic process [inference]

glycosylceramide catabolic process [inference]

galactosylceramide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

epithelial cell differentiation [inference]

epithelial cell differentiation involved in prostate gland development

cell development [inference]

corneocyte development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

localization within membrane [inference]

ganglioside GM1 transport to membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

inclusion body assembly

membrane assembly [inference]

cornified envelope assembly

membrane organization [inference]

plasma membrane organization [inference]

cornified envelope assembly

membrane assembly [inference]

cornified envelope assembly

export from cell [inference]

secretion by cell [inference]

protein secretion

reproductive process [inference]

developmental process involved in reproduction [inference]

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

T cell activation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

alpha-beta T cell activation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

system process [inference]

renal system process [inference]

micturition

excretion [inference]

micturition

nervous system process

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

locomotory behavior [inference]

walking behavior

organ growth [inference]

prostate gland growth

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure development [inference]

cell development [inference]

corneocyte development

animal gross anatomical part developmental process [inference]

cochlea development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation [inference]

alpha-beta T cell differentiation [inference]

NK T cell differentiation

cell differentiation in hindbrain [inference]

cerebellar Purkinje cell differentiation

neuron differentiation [inference]

central nervous system neuron differentiation [inference]

cerebellar Purkinje cell differentiation

epithelial cell differentiation [inference]

epithelial cell differentiation involved in prostate gland development

cell development [inference]

corneocyte development

growth [inference]

developmental growth

organ growth [inference]

prostate gland growth

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

protein localization to extracellular region [inference]

protein secretion

establishment of localization [inference]

transport [inference]

lipid transport [inference]

ceramide transport [inference]

ganglioside GM1 transport to membrane

glycolipid transport

ganglioside GM1 transport to membrane

protein transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

ganglioside GM1 transport to membrane

secretion [inference]

secretion by cell [inference]

protein secretion

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

nitrogen compound transport [inference]

ceramide transport [inference]

ganglioside GM1 transport to membrane

export from cell [inference]

secretion by cell [inference]

protein secretion

carbohydrate derivative transport [inference]

glycolipid transport

ganglioside GM1 transport to membrane

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

vacuolar transport [inference]

lysosomal transport

localization within membrane [inference]

ganglioside GM1 transport to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	ISO	GO_REF
extracellular region	EXP	PMID PMID PMID
extracellular region	IEA	GO_REF
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

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GO Term	Evidence Code	Reference
G protein-coupled receptor binding	ISO	GO_REF
protease binding	ISO	GO_REF
phospholipid binding	ISO	GO_REF
lipid antigen binding	ISO	GO_REF
identical protein binding	ISO	GO_REF

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

lipid antigen binding

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

scaffold protein binding

lipid binding [inference]

sphingolipid binding [inference]

glycosphingolipid binding [inference]

ganglioside binding [inference]

ceramide binding [inference]

ganglioside binding [inference]

glycolipid binding [inference]

glycosphingolipid binding [inference]

ganglioside binding [inference]

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

ganglioside GM3 binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

ganglioside GM3 binding

carbohydrate derivative binding [inference]

glycolipid binding [inference]

glycosphingolipid binding [inference]

ganglioside binding [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MYALALLASLLVTALTSPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNSETAARCNAVDHCKRHVWN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
80	N-linked (GlcNAc...) asparagine	UniProt
214	N-linked (GlcNAc...) asparagine	UniProt
331	N-linked (GlcNAc...) asparagine	UniProt
456	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
G alpha (i) signalling events	Rattus norvegicus
Glycosphingolipid catabolism	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus
Peptide ligand-binding receptors	Rattus norvegicus
Platelet degranulation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements