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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Summary
- UniProt ID
- P11177
- Gene Symbol
-
- PDHB
- PHE1B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Glucose metabolism
- Mitochondrion
- Oxidoreductase
- Phosphoprotein
- Pyruvate
- Reference proteome
- Thiamine pyrophosphate
- Transit peptide
- Tricarboxylic acid cycle
- Gene Ontology (GO)
| GO Term |
|---|
| glucose metabolic process |
| tricarboxylic acid cycle |
| acetyl-CoA biosynthetic process from pyruvate |
| GO Term |
|---|
| nucleus |
| mitochondrion |
| mitochondrial matrix |
| mitochondrial pyruvate dehydrogenase complex |
| pyruvate dehydrogenase complex |
| nucleoplasm |
| GO Term |
|---|
| pyruvate dehydrogenase (acetyl-transferring) activity |
Sequence
MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 5 |
|
|||
| 282 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Mitochondrial protein degradation | Homo sapiens |
| PDH complex synthesizes acetyl-CoA from PYR | Homo sapiens |
| Regulation of pyruvate dehydrogenase (PDH) complex | Homo sapiens |
| Signaling by Retinoic Acid | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0060548 | luminal breast carcinoma A | |
| DOID:11847 | coronary thrombosis | |
| DOID:1612 | breast cancer | |
| DOID:1909 | melanoma | |
| DOID:3112 | papillary adenocarcinoma | |
| DOID:3459 | breast carcinoma | |
| DOID:3649 | pyruvate decarboxylase deficiency | |
| DOID:3650 | lactic acidosis | |
| DOID:3651 | pyruvate carboxylase deficiency disease |
