GlyCosmos Portal

Submissions

Angiotensin-converting enzyme

Summary

UniProt ID

P12821

Gene Symbol

ACE
DCP
DCP1

Organism

Homo sapiens (human)

External Links

GlyConnect

1011

GlyGen

P12821

PubChem

P12821

The Human Metabolome Database

HMDBP01710

Annotation

Keyword

3D-structure
Alternative promoter usage
Alternative splicing
Calmodulin-binding
Carboxypeptidase
Cell membrane
Cytoplasm
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Zinc

Gene Ontology (GO)

Displaying entries **1 - 10** of 56 in total

1

2

3

4

5

6

Next ›

Last »
GO Term
response to hypoxia
response to xenobiotic stimulus
regulation of vasoconstriction
vasoconstriction
eating behavior
positive regulation of vasoconstriction
negative regulation of glucose import
blood vessel diameter maintenance
angiotensin maturation
regulation of renal output by angiotensin

Displaying **all 10** entries
GO Term
extracellular region
extracellular space
lysosome
plasma membrane
extracellular exosome
brush border membrane
endosome
external side of plasma membrane
basal plasma membrane
sperm midpiece

Displaying entries **1 - 10** of 17 in total

1

2

Next ›

Last »
GO Term
peptidase activity
heterocyclic compound binding
chloride ion binding
mitogen-activated protein kinase kinase binding
bradykinin receptor binding
endopeptidase activity
exopeptidase activity
tripeptidyl-peptidase activity
actin binding
carboxypeptidase activity

Site Annotations

Displaying **all 2** entries
Position	Description
523	Not glycosylated
1225	Not glycosylated

Annotation information from UniProt.

Sequence

MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 23 in total

1

2

3

Next ›

Last »
Position	Description	PubMed ID	GlyTouCan ID	Source
38	N-linked (GlcNAc...) asparagine	20826823 9013598		UniProt GlyGen
54	N-linked (GlcNAc...) asparagine	16476442 20826823 9013598		UniProt GlyGen
74	N-linked (GlcNAc...) asparagine	16476442 20826823 26403559		UniProt GlyGen
103	N-linked (GlcNAc...) asparagine	21810173 24297181 8626443		UniProt
111	N-linked (GlcNAc...) asparagine	19159218 20826823 9013598	G53075ES G05962QB G30740WO G70232NH G55132BD G69521XL G35541EV G13131HA G49755GI G16125XL G68490OW G86880BF G28622IK G80479JV G85282JO G87123QX G79666IR G92135MA G98611JV G02528FI G45395BF G07246CJ G10819WX G40926MX G14972EH G43223CG G49906RN G70441OD G87661QW G83646BJ G60033FS G41071NU G07755XJ G70619PT G65184UU G42124LM G62765YT	UniProt GlyGen
121	N-linked (GlcNAc...) asparagine	8626443		UniProt
140	N-linked (GlcNAc...) asparagine	21810173 24297181 8626443		UniProt
146	N-linked (GlcNAc...) asparagine	16476442 20826823 9013598	G88619MM G10019LZ G11629QQ G07246CJ G82830MN G48414YA G49906RN G27058EU G41071NU G65184UU G42124LM G90659AW G72790NZ	UniProt GlyGen GlyConnect
160	N-linked (GlcNAc...) asparagine	20826823		UniProt GlyGen
318	N-linked (GlcNAc...) asparagine	16476442		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Metabolism of Angiotensinogen to Angiotensins	Homo sapiens

Human Protein Atlas

ENSG00000159640

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **1 - 10** of **927** in total

1

2

3

4

5

…

Next ›

Last »
DO ID	Disease Name	Source
DOID:0002116	pterygium	DisGeNET
DOID:0014667	disease of metabolism	DisGeNET
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050083	Keshan disease	DisGeNET
DOID:0050152	aspiration pneumonia	DisGeNET DisGeNET
DOID:0050156	idiopathic pulmonary fibrosis	DisGeNET
DOID:0050328	congenital hypothyroidism	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050430	multiple endocrine neoplasia type 2A	DisGeNET
DOID:0050452	mevalonic aciduria	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements