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Clusterin

Summary

UniProt ID: P14018
Gene Symbol: CLU T64
Gene ID
Organism: Coturnix japonica (Japanese quail)

External Links

PubChem: P14018
Re-Glyco: P14018

Annotation

Keyword: Chaperone Cytoplasm Cytoplasmic vesicle Disulfide bond Endoplasmic reticulum Glycoprotein Membrane Mitochondrion Nucleus Reference proteome Secreted Signal Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
negative regulation of activation of membrane attack complex	ISS	GO_REF
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA	GO_REF
regulation of cell population proliferation	ISS	GO_REF
positive regulation of apoptotic process	ISS	GO_REF
negative regulation of complement activation	ISS	GO_REF

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

negative regulation of cellular process [inference]

negative regulation of cell killing [inference]

negative regulation of complement-dependent cytotoxicity

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

negative regulation of activation of membrane attack complex

negative regulation of complement activation

negative regulation of activation of membrane attack complex

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation

negative regulation of activation of membrane attack complex

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cell killing [inference]

negative regulation of cell killing [inference]

negative regulation of complement-dependent cytotoxicity

regulation of complement-dependent cytotoxicity [inference]

negative regulation of complement-dependent cytotoxicity

regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

negative regulation of cellular process [inference]

negative regulation of cell killing [inference]

negative regulation of complement-dependent cytotoxicity

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
nucleus	ISS	GO_REF
nucleus	IEA	GO_REF GO_REF
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

chromaffin granule

Displaying **all 2** entries
GO Term	Evidence Code	Reference
misfolded protein binding	IEA	GO_REF
protein sequestering activity	ISS	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

misfolded protein binding

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MELPLLALLSLGLVCQGGQGLVPPNELKQLSAAGSKYIDAEVENAINGVKQMKTLMDKTSKEHQAMLHTLEETKKKKEEAVKLALEKEKQLAEKQEVCNETMLSLWEECKPCLKHTCMRVYSKMCHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDDLLDREQRQERRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFGGFREAFVPPVQRVHLVPRRRLSRELHPFFQHPMHGFHRLFQPLFEMTQHMLDGGHGAWEHPLGGFATESRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPVQSQLREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLGNLTQGNDGFLQVTTVFSKTPNLEDPSAPADTQVTVQLFDSEPLSLTVPGDISWDDPRFMEIVAEQALQHYKQNNTIE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
99	N-linked (GlcNAc...) asparagine	UniProt
141	N-linked (GlcNAc...) asparagine	UniProt
278	N-linked (GlcNAc...) asparagine	UniProt
355	N-linked (GlcNAc...) asparagine	UniProt
375	N-linked (GlcNAc...) asparagine	UniProt
447	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements