GlyCosmos Portal

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Insulin receptor

Summary

UniProt ID

P15127

Gene Symbol

Insr

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P15127
PubChem: P15127

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Lysosome
Phosphoprotein
Receptor
Reference proteome
Repeat
S-nitrosylation
Signal
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **21 - 30** of 71 in total

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GO Term
response to nutrient levels
response to estradiol
response to insulin
response to testosterone
positive regulation of protein-containing complex disassembly
positive regulation of nitric oxide biosynthetic process
fat cell differentiation
negative regulation of glycogen biosynthetic process
positive regulation of glycogen biosynthetic process
positive regulation of mitotic nuclear division

Displaying entries **1 - 10** of 14 in total

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GO Term
lysosome
plasma membrane
insulin receptor complex
endosome
late endosome
external side of plasma membrane
neuronal cell body membrane
yolk
membrane
axon

Displaying entries **1 - 10** of 21 in total

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GO Term
cargo receptor activity
insulin binding
protein-containing complex binding
protein kinase binding
PTB domain binding
protein domain specific binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
3-phosphoinositide-dependent protein kinase binding

Annotation information from UniProt.

Sequence

MGSGRGCETTAVPLLMAVAVAGGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDYVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGNVTATTPTLPDFPNISSTIAPTSHEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERSGVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGCREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **11 - 18** of 18 in total

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Position	Description	GlyTouCan ID	Source
540	N-linked (GlcNAc...) asparagine		UniProt GlyGen
634	N-linked (GlcNAc...) asparagine		UniProt GlyGen
652	N-linked (GlcNAc...) asparagine		UniProt GlyGen
699	N-linked (GlcNAc...) asparagine		UniProt GlyGen
770	N-linked (GlcNAc...) asparagine		UniProt GlyGen
783	N-linked (GlcNAc...) asparagine		UniProt GlyGen
921	N-linked (GlcNAc...) asparagine	G09775CH G31852PQ G37135JQ G02815KT G55220VL	UniProt GlyGen
934	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
IRS activation	Rattus norvegicus
Insulin receptor recycling	Rattus norvegicus
Insulin receptor signalling cascade	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus
Signal attenuation	Rattus norvegicus
Signaling by Insulin receptor	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements