GlyCosmos Portal

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Insulin receptor

Summary

UniProt ID

P15208

Gene Symbol

Insr

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003397

GlyConnect

2393

GlyGen

P15208

PubChem

P15208

The O-GlcNAc Database

P15208

Annotation

Keyword

3D-structure
ATP-binding
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Lysosome
Phosphoprotein
Receptor
Reference proteome
Repeat
S-nitrosylation
Signal
Transmembrane helix
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 44 in total

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GO Term
G protein-coupled receptor signaling pathway
positive regulation of cell population proliferation
insulin receptor signaling pathway
epidermis development
male gonad development
animal organ morphogenesis
negative regulation of gene expression
positive regulation of cell migration
positive regulation of phosphorylation
glucose homeostasis

Displaying entries **1 - 10** of 17 in total

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GO Term
caveola
endosome
late endosome
nuclear envelope
lysosome
plasma membrane
insulin receptor complex
membrane
axon
nuclear lumen

Displaying entries **11 - 20** of 20 in total

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GO Term
insulin binding
protein-containing complex binding
protein kinase binding
PTB domain binding
protein domain specific binding
lipoic acid binding
insulin-like growth factor I binding
insulin-like growth factor II binding
3-phosphoinositide-dependent protein kinase binding
insulin receptor substrate binding

Annotation information from UniProt.

Sequence

MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine			UniProt GlyGen
52	N-linked (GlcNAc...) asparagine		G07755XJ	UniProt GlyGen
105	N-linked (GlcNAc...) asparagine		G41247ZX	UniProt GlyGen
138	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
242	N-linked (GlcNAc...) asparagine		G29545VG G05724UK G39188ZX	GlycoProtDB UniProt GlyGen GlyConnect
282	N-linked (GlcNAc...) asparagine		G80920RR	GlycoProtDB UniProt GlyGen
322	N-linked (GlcNAc...) asparagine			UniProt GlyGen
364	N-linked (GlcNAc...) asparagine		G02815KT	GlycoProtDB UniProt GlyGen
424	N-linked (GlcNAc...) asparagine		G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
445	N-linked (GlcNAc...) asparagine	19349973 19656770	G19973ZD G70101JE G64527OM G06110VR	GlycoProtDB UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
IRS activation	Mus musculus
Insulin receptor recycling	Mus musculus
Insulin receptor signalling cascade	Mus musculus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mus musculus
Signal attenuation	Mus musculus
Signaling by Insulin receptor	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements