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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Beta-1,4-galactosyltransferase 1
Summary
- UniProt ID
- P15291
- Gene Symbol
-
- B4GALT1
- GGTB2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Cell membrane
- Cell projection
- Congenital disorder of glycosylation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosyltransferase
- Golgi apparatus
- Lipid metabolism
- Manganese
- Metal-binding
- Reference proteome
- Secreted
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| extracellular space |
| Golgi apparatus |
| plasma membrane |
| membrane |
| secretory granule membrane |
| protein-containing complex |
| azurophil granule membrane |
| extracellular exosome |
| basolateral plasma membrane |
Sequence
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPLQGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVPHTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYDYTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 57 |
|
|||
| 58 |
|
|||
| 64 |
|
|||
| 66 |
|
|||
| 79 |
|
|||
| 113 | N-linked (GlcNAc...) asparagine |
|
||
| 115 |
|
|||
| 122 |
|
|||
| 123 |
|
|||
|
|
G49108TO
G43417UB
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) | Homo sapiens |
| Defective B4GALT1 causes CDG-2d | Homo sapiens |
| Interaction With Cumulus Cells And The Zona Pellucida | Homo sapiens |
| Keratan sulfate biosynthesis | Homo sapiens |
| Lactose synthesis | Homo sapiens |
| N-Glycan antennae elongation | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Pre-NOTCH Processing in Golgi | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110749 | type 1 diabetes mellitus 10 | |
| DOID:0110750 | type 1 diabetes mellitus 11 | |
| DOID:0110751 | type 1 diabetes mellitus 12 | |
| DOID:0110752 | type 1 diabetes mellitus 13 | |
| DOID:0110753 | type 1 diabetes mellitus 15 | |
| DOID:0110754 | type 1 diabetes mellitus 17 | |
| DOID:0110755 | type 1 diabetes mellitus 18 | |
| DOID:0110756 | type 1 diabetes mellitus 19 | |
| DOID:0110757 | type 1 diabetes mellitus 20 | |
| DOID:0110758 | type 1 diabetes mellitus 21 |
