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Insulin-like growth factor-binding protein 3

Summary

UniProt ID

P15473

Gene Symbol

Igfbp3
Igfbp-3

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P15473

Annotation

Keyword

Apoptosis
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 30 in total

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GO Term
positive regulation of cardiac muscle cell apoptotic process
response to organic cyclic compound
negative regulation of smooth muscle cell migration
response to insulin
positive regulation of apoptotic process
type B pancreatic cell proliferation
positive regulation of myoblast differentiation
negative regulation of smooth muscle cell proliferation
cellular response to estradiol stimulus
negative regulation of testosterone secretion

Displaying **all 6** entries
GO Term
platelet alpha granule
insulin-like growth factor ternary complex
insulin-like growth factor binary complex
heterochromatin
extracellular space
nucleus

Displaying **all 5** entries
GO Term
protein tyrosine phosphatase activator activity
insulin-like growth factor I binding
insulin-like growth factor II binding
fibronectin binding
insulin-like growth factor binding

Annotation information from UniProt.

Sequence

MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALAQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLKALLNGRGFCANASAASNLSAYLPSQPSPGNTTESEEDHNAGSVESQVVPSTHRVTDSKFHPLHSKMEVIIKGQARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
118	N-linked (GlcNAc...) asparagine	UniProt
124	N-linked (GlcNAc...) asparagine	UniProt
137	N-linked (GlcNAc...) asparagine	UniProt
200	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Post-translational protein phosphorylation	Rattus norvegicus
Regulation of IGF Activity by IGFBP	Rattus norvegicus
TP53 Regulates Transcription of Death Receptors and Ligands	Rattus norvegicus