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6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Summary

UniProt ID

P16118

Gene Symbol

PFKFB1
F6PK
PFRX

Organism

Homo sapiens (human)

External Links

GlyGen: P16118
PubChem: P16118
The Human Metabolome Database: HMDBP00799
The O-GlcNAc Database: P16118
O-GlcNAcAtlas: P16118

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Hydrolase
Kinase
Multifunctional enzyme
Phosphoprotein
Reference proteome

Gene Ontology (GO)

Displaying entries **1 - 10** of 11 in total

1

2

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GO Term
gluconeogenesis
animal organ regeneration
response to insulin
response to glucagon
response to glucocorticoid
response to cAMP
fructose metabolic process
glycolytic process
negative regulation of glycolytic process through fructose-6-phosphate
fructose 2,6-bisphosphate metabolic process

Displaying **all 2** entries
GO Term
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
cytosol

Displaying **all 6** entries
GO Term
identical protein binding
6-phosphofructo-2-kinase activity
fructose-2,6-bisphosphate 2-phosphatase activity
ATP binding
fructose-6-phosphate binding
kinase binding

Annotation information from UniProt.

Sequence

MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
2			G49108TO	GlyGen The O-GlcNAc Database
9			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
PKA-mediated phosphorylation of key metabolic factors	Homo sapiens
PP2A-mediated dephosphorylation of key metabolic factors	Homo sapiens
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:10534	stomach cancer	DisGeNET
DOID:162	cancer	DisGeNET
DOID:2018	hyperinsulinism	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements