ATP-dependent 6-phosphofructokinase, liver type

Summary
UniProt ID
P17858
Gene Symbol
  • PFKL
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
P17858
PubChem
P17858
The Human Metabolome Database
HMDBP00758
The O-GlcNAc Database
P17858
RaftProt
P17858
O-GlcNAcAtlas
P17858
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Allosteric enzyme
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Glycolysis
  • Glycoprotein
  • Kinase
  • Magnesium
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
Gene Ontology (GO)
Sequence
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
399
464
529 O-linked (GlcNAc) serine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Glycolysis Homo sapiens
Neutrophil degranulation Homo sapiens
Disease
Displaying entries 1 - 10 of 27 in total
DO ID Disease Name Source
DOID:0060162 dentatorubral-pallidoluysian atrophy
DOID:0080220 obsolete major affective disorder 1
DOID:0080221 obsolete major affective disorder 2
DOID:0111040 glycogen storage disease IXd
DOID:0111041 glycogen storage disease IXb
DOID:0111042 glycogen storage disease IXa
DOID:0111043 glycogen storage disease IXc
DOID:0111452 progressive myoclonus epilepsy 1A
DOID:14250 Down syndrome
DOID:1657 ventricular septal defect

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024