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Gamma-aminobutyric acid receptor subunit beta-1

Summary

UniProt ID

P18505

Gene Symbol

GABRB1

Gene ID

2560

Organism

Homo sapiens (human)

External Links

PubChem: P18505
The Human Metabolome Database: HMDBP08204
Re-Glyco: P18505

Annotation

Keyword

Alternative splicing
Cell membrane
Chloride channel
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

1

2

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GO Term
chloride channel complex
Schaffer collateral - CA1 synapse
GABA-ergic synapse
postsynaptic specialization membrane
GABA-A receptor complex
nuclear envelope
plasma membrane
dendrite
neuron projection
synapse

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 9** entries
GO Term
monoatomic ion transport
signal transduction
response to toxic substance
central nervous system neuron development
response to progesterone
chloride transmembrane transport
gamma-aminobutyric acid signaling pathway
ovulation cycle
cellular response to histamine

Displaying **all 8** entries
GO Term
GABA-A receptor activity
ligand-gated monoatomic ion channel activity
neurotransmitter receptor activity
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GABA receptor binding
GABA-gated chloride ion channel activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential

Annotation information from UniProt.

Sequence

MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
105	N-linked (GlcNAc...) asparagine			UniProt
174	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
GABA receptor activation	Homo sapiens
Signaling by ERBB4	Homo sapiens

Disease

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080428	developmental and epileptic encephalopathy 45	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements