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Alpha-2C adrenergic receptor

Summary

UniProt ID

P18825

Gene Symbol

ADRA2C
ADRA2L2
ADRA2RL2

Gene ID

152

Organism

Homo sapiens (human)

External Links

PubChem: P18825
The Human Metabolome Database: HMDBP10771
Re-Glyco: P18825

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
plasma membrane
endosome
cytoplasm

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 14 in total

1

2

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GO Term
positive regulation of MAPK cascade
positive regulation of neuron differentiation
regulation of vasoconstriction
adenylate cyclase-activating adrenergic receptor signaling pathway
regulation of smooth muscle contraction
G protein-coupled receptor signaling pathway
cell-cell signaling
negative regulation of norepinephrine secretion
platelet activation
negative regulation of epinephrine secretion

Displaying **all 6** entries
GO Term
alpha2-adrenergic receptor activity
alpha-2A adrenergic receptor binding
epinephrine binding
guanyl-nucleotide exchange factor activity
protein homodimerization activity
protein heterodimerization activity

Annotation information from UniProt.

Sequence

MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
19	N-linked (GlcNAc...) asparagine			UniProt
33	N-linked (GlcNAc...) asparagine			UniProt

Feature

Domains & sites

PTM

ProtVista

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Adrenaline signalling through Alpha-2 adrenergic receptor	Homo sapiens
Adrenaline,noradrenaline inhibits insulin secretion	Homo sapiens
Adrenoceptors	Homo sapiens
G alpha (i) signalling events	Homo sapiens
G alpha (z) signalling events	Homo sapiens
Surfactant metabolism	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6000	congestive heart failure	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements