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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Myeloid cell surface antigen CD33
Summary
- UniProt ID
- P20138
- Gene Symbol
-
- CD33
- SIGLEC3
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P20138
- PubChem
- P20138
- The Human Metabolome Database
- HMDBP14336
- The O-GlcNAc Database
- P20138
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell adhesion
- Cell membrane
- Disulfide bond
- Glycoprotein
- Immunoglobulin domain
- Lectin
- Peroxisome
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| positive regulation of protein secretion |
| negative regulation of calcium ion transport |
| negative regulation of monocyte activation |
| GO Term |
|---|
| Golgi apparatus |
| plasma membrane |
| tertiary granule membrane |
| peroxisome |
| nucleoplasm |
| external side of plasma membrane |
| cell surface |
| specific granule membrane |
| GO Term |
|---|
| signaling receptor activity |
| carbohydrate binding |
| protein phosphatase binding |
| sialic acid binding |
Sequence
MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYWFREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRMERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWLSAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTTGIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTHPTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSEVRTQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 99 |
|
|
||
| 100 | N-linked (GlcNAc...) asparagine | |||
| 113 | N-linked (GlcNAc...) asparagine |
|
||
| 160 | N-linked (GlcNAc...) asparagine |
|
||
| 209 | N-linked (GlcNAc...) asparagine |
|
||
| 216 |
|
|||
| 230 | N-linked (GlcNAc...) asparagine |
|
||
| 239 |
|
|||
| 240 |
|
|||
|
|
G59626AS
G57321FI
G43417UB
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060402 | chromosome 17p13.1 deletion syndrome | |
| DOID:0060469 | Miller-Dieker lissencephaly syndrome | |
| DOID:0060597 | atypical chronic myeloid leukemia, BCR-ABL1 negative | |
| DOID:0070323 | childhood acute myeloid leukemia | |
| DOID:0080144 | childhood acute lymphocytic leukemia | |
| DOID:0080145 | childhood T-cell acute lymphoblastic leukemia | |
| DOID:0080147 | lymphoblastic lymphoma | |
| DOID:0080148 | T-cell childhood lymphoblastic lymphoma | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080348 | Alzheimer's disease 1 |
