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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
B-cell receptor CD22
Summary
- UniProt ID
- P20273
- Gene Symbol
-
- CD22
- SIGLEC2
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P20273
- PubChem
- P20273
- The Human Metabolome Database
- HMDBP14330
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell adhesion
- Cell membrane
- Disulfide bond
- Glycoprotein
- Immunoglobulin domain
- Isopeptide bond
- Lectin
- Phosphoprotein
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| membrane |
| extracellular exosome |
| early endosome |
| external side of plasma membrane |
| cell surface |
| neuronal cell body membrane |
| recycling endosome |
| GO Term |
|---|
| carbohydrate binding |
| IgM binding |
| signaling receptor binding |
| protein phosphatase binding |
| sialic acid binding |
| CD4 receptor binding |
Sequence
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 61 |
|
|
||
| 65 |
|
|
||
| 67 | N-linked (GlcNAc...) asparagine |
|
||
| 99 |
|
|
||
| 101 | N-linked (GlcNAc...) asparagine |
|
||
| 112 | N-linked (GlcNAc...) asparagine |
|
||
| 135 | N-linked (GlcNAc...) asparagine | |||
| 164 | N-linked (GlcNAc...) asparagine |
|
||
| 231 | N-linked (GlcNAc...) asparagine |
|
||
| 363 | N-linked (GlcNAc...) asparagine |
|
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | Homo sapiens |
| CD22 mediated BCR regulation | Homo sapiens |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:65 | connective tissue disease | |
| DOID:660 | adrenal cortex cancer | |
| DOID:6688 | autoimmune lymphoproliferative syndrome | |
| DOID:684 | hepatocellular carcinoma | |
| DOID:707 | B-cell lymphoma | |
| DOID:711 | refractory hairy cell leukemia | |
| DOID:713 | HCL-V | |
| DOID:7148 | rheumatoid arthritis | |
| DOID:7693 | abdominal aortic aneurysm | |
| DOID:7757 | childhood leukemia |
