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MIRAGE
Ras GTPase-activating protein 1
Summary
- UniProt ID
- P20936
- Gene Symbol
-
- GAP
- RASA
- RASA1
- Gene ID
- 5921.0
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- GTPase activation
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- SH3 domain
- Tumor suppressor
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| cytosol |
| ruffle |
| GO Term |
|---|
| signaling receptor binding |
| phosphotyrosine residue binding |
| potassium channel inhibitor activity |
| GTPase activity |
| GTPase activator activity |
| GTPase binding |
Sequence
MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGTLGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR
Glycosylation Sites
G20528HD
G41071NU
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downstream signal transduction | Homo sapiens |
| EPHB-mediated forward signaling | Homo sapiens |
| PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | Homo sapiens |
| Regulation of RAS by GAPs | Homo sapiens |
| VEGFR2 mediated cell proliferation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:11294 | arteriovenous malformation | |
| DOID:2513 | basal cell carcinoma |
