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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Summary

UniProt ID

P22413

Gene Symbol

ENPP1
M6S1
NPPS
PC1
PDNP1

Organism

Homo sapiens (human)

External Links

GlyConnect

1196

GlyGen

P22413

PubChem

P22413

The Human Metabolome Database

HMDBP00119

The O-GlcNAc Database

P22413

Annotation

Keyword

3D-structure
Biomineralization
Calcium
Cell membrane
Diabetes mellitus
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Obesity
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal-anchor
Transmembrane helix
Zinc

Gene Ontology (GO)

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GO Term
generation of precursor metabolites and energy
phosphate-containing compound metabolic process
immune response
response to inorganic substance
gene expression
cellular response to insulin stimulus
nucleic acid metabolic process
bone mineralization
negative regulation of cell growth
melanocyte differentiation

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GO Term
extracellular space
lysosomal membrane
plasma membrane
membrane
basolateral plasma membrane
cell surface

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GO Term
nucleic acid binding
scavenger receptor activity
calcium ion binding
polysaccharide binding
3'-phosphoadenosine 5'-phosphosulfate binding
protein homodimerization activity
ATP diphosphatase activity
phosphatase activity
3',5'-cyclic-AMP phosphodiesterase activity
exonuclease activity

Annotation information from UniProt.

Sequence

MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Vitamin B2 (riboflavin) metabolism	Homo sapiens
Vitamin B5 (pantothenate) metabolism	Homo sapiens

Human Protein Atlas

ENSG00000197594

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

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DO ID	Disease Name	Source
DOID:0110754	type 1 diabetes mellitus 17	DisGeNET
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET
DOID:0110756	type 1 diabetes mellitus 19	DisGeNET
DOID:0110757	type 1 diabetes mellitus 20	DisGeNET
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110759	type 1 diabetes mellitus 22	DisGeNET
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET
DOID:0110761	type 1 diabetes mellitus 24	DisGeNET
DOID:0110946	autosomal recessive osteopetrosis 7	DisGeNET
DOID:0111063	hyperphosphatemic familial tumoral calcinosis	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

International Collaboration

Acknowledgements