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Fibroblast growth factor receptor 4

Summary
UniProt ID
P22455
Gene Symbol
  • FGFR4
  • JTK2
  • TKF
Organism
Homo sapiens (human)
External Links
GlycoProtDB
GPDB0011610
GlyConnect
GlyGen
P22455
PubChem
P22455
The Human Metabolome Database
HMDBP01234
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Alternative splicing
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Endoplasmic reticulum
  • Endosome
  • Glycoprotein
  • Immunoglobulin domain
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
  • Tyrosine-protein kinase
  • Ubl conjugation
Gene Ontology (GO)
Annotation information from UniProt.
Sequence
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 8 entries
Position Description PubMed ID GlyTouCan ID Source
112 N-linked (GlcNAc...) asparagine
177
258 N-linked (GlcNAc...) asparagine
260
290 N-linked (GlcNAc...) asparagine
311 N-linked (GlcNAc...) asparagine
322 N-linked (GlcNAc...) asparagine
508
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 14 in total
Pathway Name Organism
Constitutive Signaling by Aberrant PI3K in Cancer Homo sapiens
FGFR4 ligand binding and activation Homo sapiens
FGFR4 mutant receptor activation Homo sapiens
FRS-mediated FGFR4 signaling Homo sapiens
Negative regulation of FGFR4 signaling Homo sapiens
PI-3K cascade:FGFR4 Homo sapiens
PI3K Cascade Homo sapiens
PI3K/AKT Signaling Homo sapiens
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Homo sapiens
Phospholipase C-mediated cascade; FGFR4 Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024