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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Fibroblast growth factor receptor 4
Summary
- UniProt ID
- P22455
- Gene Symbol
-
- FGFR4
- JTK2
- TKF
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011610
- GlyConnect
- GlyGen
- P22455
- PubChem
- P22455
- The Human Metabolome Database
- HMDBP01234
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disulfide bond
- Endoplasmic reticulum
- Endosome
- Glycoprotein
- Immunoglobulin domain
- Phosphoprotein
- Receptor
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| Golgi apparatus |
| plasma membrane |
| transport vesicle |
| receptor complex |
| endosome |
| endoplasmic reticulum |
| GO Term |
|---|
| heparin binding |
| fibroblast growth factor receptor activity |
| fibroblast growth factor binding |
| ATP binding |
Sequence
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 112 | N-linked (GlcNAc...) asparagine |
|
||
| 177 |
|
|||
| 258 | N-linked (GlcNAc...) asparagine | |||
| 260 |
|
|||
| 290 | N-linked (GlcNAc...) asparagine | |||
| 311 | N-linked (GlcNAc...) asparagine | |||
| 322 | N-linked (GlcNAc...) asparagine |
|
||
| 508 |
|
G22310AV
G80920RR
G43417UB
G13694XX
G48414YA
G33791AF
G86795LJ
G47748JZ
G84452RH
G83460ZZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| FGFR4 ligand binding and activation | Homo sapiens |
| FGFR4 mutant receptor activation | Homo sapiens |
| FRS-mediated FGFR4 signaling | Homo sapiens |
| Negative regulation of FGFR4 signaling | Homo sapiens |
| PI-3K cascade:FGFR4 | Homo sapiens |
| PI3K Cascade | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
| Phospholipase C-mediated cascade; FGFR4 | Homo sapiens |
