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Beta-galactosidase

Summary

UniProt ID: P23780
Gene Symbol: Glb1 Bgl Glb-1
Gene ID: 12091
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003499
GlyGen: P23780
PubChem: P23780
Re-Glyco: P23780

Annotation

Keyword: 3D-structure Disulfide bond Glycoprotein Glycosidase Lysosome Reference proteome Signal Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
carbohydrate metabolic process	ISO	GO_REF
carbohydrate metabolic process	IEA	GO_REF GO_REF
glycoprotein catabolic process	ISO	GO_REF
glycoprotein catabolic process	IMP	PMID
glycoprotein catabolic process	IEA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

galactose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

galactose catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan catabolic process

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process [inference]

galactose catabolic process

hexose catabolic process [inference]

galactose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

galactose catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

galactose catabolic process

lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

lipid catabolic process [inference]

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

sphingolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

ceramide catabolic process [inference]

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan catabolic process

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process [inference]

galactose catabolic process

hexose catabolic process [inference]

galactose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

galactose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

galactose catabolic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

keratan sulfate proteoglycan metabolic process [inference]

keratan sulfate proteoglycan catabolic process

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

carbohydrate derivative catabolic process [inference]

glycoprotein catabolic process

proteoglycan catabolic process [inference]

keratan sulfate proteoglycan catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

ganglioside metabolic process [inference]

ganglioside catabolic process

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

glycolipid catabolic process [inference]

glycosphingolipid catabolic process [inference]

ganglioside catabolic process

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisone

response to chemical [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisone

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to cortisone

response to ketone [inference]

response to cortisone

response to Thyroglobulin triiodothyronine

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
cytoplasm	ISO	GO_REF
cytoplasm	IDA	PMID
cytoplasm	IEA	GO_REF
lysosome	ISS	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

lytic vacuole [inference]

lysosome

Golgi apparatus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
beta-galactosidase activity	ISO	GO_REF GO_REF
beta-galactosidase activity	EXP	PMID
beta-galactosidase activity	IDA	PMID PMID PMID PMID
beta-galactosidase activity	IMP	PMID
beta-galactosidase activity	IEA	GO_REF GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

galactosidase activity [inference]

beta-galactosidase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

carbohydrate derivative binding [inference]

galactoside binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLRVPLCTPLPLLALLQLLGAAHGIYNVTQRTFKLDYSRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLNAIQMYVPWNFHEPQPGQYEFSGDRDVEHFIQLAHELGLLVILRPGPYICAEWDMGGLPAWLLEKQSIVLRSSDPDYLVAVDKWLAVLLPKMKPLLYQNGGPIITVQVENEYGSYFACDYDYLRFLVHRFRYHLGNDVILFTTDGASEKMLKCGTLQDLYATVDFGTGNNITQAFLVQRKFEPKGPLINSEFYTGWLDHWGKPHSTVKTKTLATSLYNLLARGANVNLYMFIGGTNFAYWNGANTPYEPQPTSYDYDAPLSEAGDLTKKYFALREVIQMFKEVPEGPIPPSTPKFAYGKVALRKFKTVAEALGILCPNGPVKSLYPLTFTQVKQYFGYVLYRTTLPQDCSNPKPIFSSPFNGVRDRAYVSVDGVPQGILDRNLMTALNIRGKAGATLDILVENMGRVNYGRFINDFKGLISNMTINSTVLTNWTVFPLNTEAMVRNHLWGREASDEGHLDGRSTSNSSDLILPTFYVGNFSIPSGIPDLPQDTFIQFPGWSKGQVWINGFNLGRYWPTMGPQKTLFVPRNILTTSAPNNITVLELEFAPCSEGTPELCTVEFVDTPVIS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	Source
27	N-linked (GlcNAc...) asparagine	UniProt GlyGen
248	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt GlyGen
500	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt GlyGen
504	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt GlyGen
510	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt GlyGen
544	N-linked (GlcNAc...) asparagine	UniProt GlyGen
557	N-linked (GlcNAc...) asparagine	UniProt GlyGen
617	N-linked (GlcNAc...) asparagine	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
CS/DS degradation	Mus musculus
Glycosphingolipid catabolism	Mus musculus
Keratan sulfate degradation	Mus musculus
Neutrophil degranulation	Mus musculus
Sialic acid metabolism	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3322	GM1 gangliosidosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements