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Tyrosine-protein kinase Lyn

Summary

UniProt ID

P25911

Gene Symbol

Gene ID

17096

Organism

Mus musculus (house mouse)

External Links

GlyGen: P25911
PubChem: P25911
The Human Metabolome Database: HMDBP13813
The O-GlcNAc Database: P25911
RaftProt: P25911
O-GlcNAcAtlas: P25911
Re-Glyco: P25911

Annotation

Keyword

3D-structure
ATP-binding
Adaptive immunity
Alternative splicing
Cell membrane
Cytoplasm
Golgi apparatus
Inflammatory response
Innate immunity
Myristate
Nucleus
Palmitate
Phosphoprotein
Proto-oncogene
Reference proteome
SH2 domain
SH3 domain
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
postsynaptic specialization, intracellular component
Golgi apparatus
cytosol
adherens junction
perinuclear region of cytoplasm
cytoplasmic side of plasma membrane
mitochondrial crista
membrane raft
integrin alpha2-beta1 complex
glutamatergic synapse

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
regulation of monocyte chemotaxis
regulation of platelet aggregation
regulation of cell adhesion mediated by integrin
DNA damage checkpoint signaling
Fc receptor mediated stimulatory signaling pathway
Fc receptor mediated inhibitory signaling pathway
regulation of B cell apoptotic process
response to sterol depletion
negative regulation of toll-like receptor 2 signaling pathway
C-X-C chemokine receptor CXCR4 signaling pathway

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GO Term
ubiquitin protein ligase binding
gamma-tubulin binding
transmembrane transporter binding
protein-containing complex binding
ephrin receptor binding
phosphoprotein binding
scaffold protein binding
phosphorylation-dependent protein binding

Annotation information from UniProt.

Sequence

MGCIKSKRKDNLNDDEVDSKTQPVRNTDRTIYVRDPTSNKQQRPVPEFHLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDPMHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
19			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
PECAM1 interactions	Mus musculus
Platelet Adhesion to exposed collagen	Mus musculus
Regulation of KIT signaling	Mus musculus
Regulation of signaling by CBL	Mus musculus
Role of LAT2/NTAL/LAB on calcium mobilization	Mus musculus
Signaling by CSF3 (G-CSF)	Mus musculus
Signaling by Erythropoietin	Mus musculus
Signaling by SCF-KIT	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements