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Syndecan-1
Summary
- UniProt ID
- P26260
- Gene Symbol
-
- Sdc1
- Synd1
- Gene ID
- 25216
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Heparan sulfate
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| plasma membrane |
| protein-containing complex |
| external side of plasma membrane |
| cell surface |
| GO Term |
|---|
| cargo receptor activity |
| identical protein binding |
| extracellular matrix binding |
Sequence
MRRAALWLWLCALALRLQPALPQIVTANVPPEDQDGSGDDSDNFSGSGTGALPDMTLSRQTPSTWKDVWLLTATPTAPEPTSRDTEATLTSILPAGEKPEEGEPVAHVEAEPDFTARDKEKEATTRPRETTQLPVTQQASTAARATTAQASVTSHPHGDVQPGLHETLAPTAPGQPDHQPPSVEDGGTSVIKEVVEDETTNQLPAGEGSGEQDFTFETSGENTAVAGVEPDLRNQSPVDEGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVAFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 37 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 43 | N-linked (GlcNAc...) asparagine |
|
||
| 45 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 47 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 209 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 219 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Rattus norvegicus |
| Cell surface interactions at the vascular wall | Rattus norvegicus |
| HS-GAG biosynthesis | Rattus norvegicus |
| HS-GAG degradation | Rattus norvegicus |
| Other interleukin signaling | Rattus norvegicus |
| Retinoid metabolism and transport | Rattus norvegicus |
| Syndecan interactions | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1168 | familial hyperlipidemia |
