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MIRAGE
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Summary
- UniProt ID
- P26284
- Gene Symbol
-
- Pdha1
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Acetylation
- Direct protein sequencing
- Glucose metabolism
- Mitochondrion
- Oxidoreductase
- Phosphoprotein
- Pyruvate
- Reference proteome
- Thiamine pyrophosphate
- Transit peptide
- Tricarboxylic acid cycle
- Gene Ontology (GO)
| GO Term |
|---|
| catalytic complex |
| mitochondrion |
| mitochondrial matrix |
| pyruvate dehydrogenase complex |
| GO Term |
|---|
| acetyl-CoA biosynthetic process from pyruvate |
| tricarboxylic acid cycle |
| glucose metabolic process |
| GO Term |
|---|
| pyruvate dehydrogenase (NAD+) activity |
| metal ion binding |
| pyruvate dehydrogenase activity |
| pyruvate dehydrogenase (acetyl-transferring) activity |
Sequence
MRKMLAAVSRVLAGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFNRGHAVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 232 |
|
|||
| 293 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| PDH complex synthesizes acetyl-CoA from PYR | Rattus norvegicus |
| Regulation of pyruvate dehydrogenase (PDH) complex | Rattus norvegicus |
| Signaling by Retinoic Acid | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3649 | pyruvate decarboxylase deficiency |
