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NKG2-A/NKG2-B type II integral membrane protein

Summary

UniProt ID

P26715

Gene Symbol

KLRC1
NKG2A

Organism

Homo sapiens (human)

External Links

GlyGen: P26715
PubChem: P26715
The O-GlcNAc Database: P26715
O-GlcNAcAtlas: P26715

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Host-virus interaction
Innate immunity
Lectin
Phosphoprotein
Receptor
Reference proteome
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
negative regulation of T cell mediated cytotoxicity
adaptive immune response
CD8-positive, gamma-delta intraepithelial T cell differentiation
cell surface receptor signaling pathway
innate immune response
regulation of natural killer cell activation
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
stimulatory C-type lectin receptor signaling pathway
natural killer cell inhibitory signaling pathway

Displaying **all 3** entries
GO Term
external side of plasma membrane
plasma membrane
receptor complex

Displaying **all 5** entries
GO Term
inhibitory MHC class Ib receptor activity
HLA-E specific inhibitory MHC class Ib receptor activity
MHC class I protein complex binding
transmembrane signaling receptor activity
carbohydrate binding

Annotation information from UniProt.

Sequence

MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHNNSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHKL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	GlyTouCan ID	Source
102	N-linked (GlcNAc...) asparagine		UniProt GlyGen
103	N-linked (GlcNAc...) asparagine		UniProt GlyGen
151	N-linked (GlcNAc...) asparagine		UniProt GlyGen
152		G49108TO	GlyGen The O-GlcNAc Database
180	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Homo sapiens

Disease

Displaying entries **1 - 10** of 84 in total

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Last »
DO ID	Disease Name	Source
DOID:12306	vitiligo	DisGeNET
DOID:12205	dengue disease	DisGeNET
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements