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CD40 ligand

Summary

UniProt ID

P27548

Gene Symbol

Cd40l
Cd40lg
Tnfsf5

Gene ID

21947

Organism

Mus musculus (house mouse)

External Links

PubChem: P27548
Re-Glyco: P27548

Annotation

Keyword

Cell membrane
Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
extracellular space
Golgi apparatus
external side of plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 16 in total

1

2

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GO Term
integrin-mediated signaling pathway
CD40 signaling pathway
positive regulation of interleukin-12 production
positive regulation of interleukin-10 production
positive regulation of interleukin-4 production
positive regulation of NF-kappaB transcription factor activity
positive regulation of endothelial cell apoptotic process
regulation of immunoglobulin production
inflammatory response
signal transduction

Displaying **all 5** entries
GO Term
CD40 receptor binding
cytokine activity
tumor necrosis factor receptor binding
integrin binding
protein serine/threonine kinase activator activity

Annotation information from UniProt.

Sequence

MIETYSQPSPRSVATGLPASMKIFMYLLTVFLITQMIGSVLFAVYLHRRLDKVEEEVNLHEDFVFIKKLKRCNKGEGSLSLLNCEEMRRQFEDLVKDITLNKEEKKENSFEMQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVMLENGKQLTVKREGLYYVYTQVTFCSNREPSSQRPFIVGLWLKPSSGSERILLKAANTHSSSQLCEQQSVHLGGVFELQAGASVFVNVTEASQVIHRVGFSSFGLLKL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
239	N-linked (GlcNAc...) asparagine			UniProt

Feature

Domains & sites

PTM

ProtVista

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mus musculus
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Mus musculus
TNFR2 non-canonical NF-kB pathway	Mus musculus