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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Choline O-acetyltransferase
Summary
- UniProt ID
- P28329
- Gene Symbol
-
- CHAT
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P28329
- PubChem
- P28329
- The Human Metabolome Database
- HMDBP00025
- The O-GlcNAc Database
- P28329
Annotation
- Keyword
-
- 3D-structure
- Acyltransferase
- Alternative splicing
- Congenital myasthenic syndrome
- Direct protein sequencing
- Disease variant
- Neurotransmitter biosynthesis
- Phosphoprotein
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| phosphatidylcholine biosynthetic process |
| neurotransmitter transport |
| neuromuscular synaptic transmission |
| acetylcholine biosynthetic process |
| GO Term |
|---|
| cytosol |
| nucleus |
| cytoplasm |
| neuron projection |
| synapse |
| GO Term |
|---|
| choline O-acetyltransferase activity |
Sequence
MGLRTAKKRGLGGGGKWKREEGGGTRGRREVRPACFLQSGGRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHLCIPAPGLTKTPILEKVPRKMAAKTPSSEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHVTQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCKETSSSKFAKAVEESLIDMRDLCSLLPPTESKPLATKEKATRPSQGHQP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 366 |
|
|||
| 372 |
|
|||
| 373 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Acetylcholine Neurotransmitter Release Cycle | Homo sapiens |
| Synthesis of PC | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110047 | Alzheimer's disease 14 | |
| DOID:0110048 | Alzheimer's disease 15 | |
| DOID:0110671 | congenital myasthenic syndrome 6 | |
| DOID:0110672 | congenital myasthenic syndrome 21 | |
| DOID:0110741 | type 1 diabetes mellitus 2 | |
| DOID:0110742 | type 1 diabetes mellitus 3 | |
| DOID:0110743 | type 1 diabetes mellitus 4 | |
| DOID:0110744 | type 1 diabetes mellitus 5 | |
| DOID:0110745 | type 1 diabetes mellitus 6 | |
| DOID:0110746 | type 1 diabetes mellitus 7 |
