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DNA repair nuclease/redox regulator APEX1

Summary

UniProt ID

P28352

Gene Symbol

Apex1
Ape
Apex
Ref1

Organism

Mus musculus (house mouse)

External Links

GlyGen: P28352
PubChem: P28352
The O-GlcNAc Database: P28352

Annotation

Keyword

3D-structure
Acetylation
Activator
Cleavage on pair of basic residues
Cytoplasm
DNA recombination
DNA repair
DNA-binding
Direct protein sequencing
Disulfide bond
Endonuclease
Endoplasmic reticulum
Exonuclease
Magnesium
Metal-binding
Mitochondrion
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repressor
S-nitrosylation
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

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GO Term
regulation of apoptotic process
cell redox homeostasis
positive regulation of gene expression via CpG island demethylation
DNA repair
positive regulation of transcription by RNA polymerase II
base-excision repair
regulation of mRNA stability
positive regulation of G1/S transition of mitotic cell cycle
DNA catabolic process
DNA recombination

Displaying **all 10** entries
GO Term
nuclear speck
mitochondrion
nucleoplasm
transcription regulator complex
endoplasmic reticulum
centrosome
nucleus
nucleolus
cytoplasm
perinuclear region of cytoplasm

Displaying entries **1 - 10** of 19 in total

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GO Term
phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
DNA-(abasic site) binding
DNA binding
RNA binding
protein-containing complex binding
metal ion binding
NF-kappaB binding
class II DNA-(apurinic or apyrimidinic site) endonuclease activity
site-specific endodeoxyribonuclease activity, specific for altered base
chromatin DNA binding

Annotation information from UniProt.

Sequence

MPKRGKKAAADDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSPSGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	Mus musculus
Displacement of DNA glycosylase by APEX1	Mus musculus
PCNA-Dependent Long Patch Base Excision Repair	Mus musculus
POLB-Dependent Long Patch Base Excision Repair	Mus musculus
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Mus musculus
Resolution of Abasic Sites (AP sites)	Mus musculus