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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
DNA repair nuclease/redox regulator APEX1
Summary
- UniProt ID
- P28352
- Gene Symbol
-
- Apex1
- Ape
- Apex
- Ref1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Cleavage on pair of basic residues
- Cytoplasm
- DNA recombination
- DNA repair
- DNA-binding
- Direct protein sequencing
- Disulfide bond
- Endonuclease
- Endoplasmic reticulum
- Exonuclease
- Magnesium
- Metal-binding
- Mitochondrion
- Nucleus
- Phosphoprotein
- RNA-binding
- Reference proteome
- Repressor
- S-nitrosylation
- Transcription regulation
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| base-excision repair |
| regulation of mRNA stability |
| positive regulation of G1/S transition of mitotic cell cycle |
| GO Term |
|---|
| nucleus |
| nucleolus |
| cytoplasm |
| perinuclear region of cytoplasm |
| nuclear speck |
| mitochondrion |
| nucleoplasm |
| transcription regulator complex |
| endoplasmic reticulum |
| centrosome |
Sequence
MPKRGKKAAADDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSPSGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Abasic sugar-phosphate removal via the single-nucleotide replacement pathway | Mus musculus |
| Displacement of DNA glycosylase by APEX1 | Mus musculus |
| PCNA-Dependent Long Patch Base Excision Repair | Mus musculus |
| POLB-Dependent Long Patch Base Excision Repair | Mus musculus |
| Resolution of AP sites via the multiple-nucleotide patch replacement pathway | Mus musculus |
| Resolution of Abasic Sites (AP sites) | Mus musculus |
