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MIRAGE
Neuroendocrine convertase 2

Summary
UniProt ID
P28841
Gene Symbol
  • Nec-2
  • Nec2
  • Pcsk2
  • Rpc2
Gene ID
25121
Organism
Rattus norvegicus (Norway rat)
GlyGen
P28841
PubChem
P28841
Re-Glyco
P28841
Annotation
Keyword
  • Cleavage on pair of basic residues
  • Cytoplasmic vesicle
  • Disulfide bond
  • Glycoprotein
  • Reference proteome
  • Secreted
  • Serine protease
  • Signal
  • Zymogen
Gene Ontology (GO)
Displaying all 10 entries
GO Term
extracellular space
membrane
secretory granule
dendrite
neuron projection
neuronal cell body
nucleoplasm
transport vesicle
perikaryon
secretory granule lumen
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MEGGCGSQWKAAGLLFCVMVFASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLQTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDEAVERSLQSILRKN
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
374 N-linked (GlcNAc...) asparagine
513 N-linked (GlcNAc...) asparagine
523 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:784 chronic kidney disease
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025