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Tyrosine-protein phosphatase non-receptor type 6

Summary

UniProt ID

P29351

Gene Symbol

Ptpn6
Hcp
Hcph
Ptp1C

Organism

Mus musculus (house mouse)

External Links

GlyGen: P29351
PubChem: P29351
The O-GlcNAc Database: P29351
RaftProt: P29351

Annotation

Keyword

Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
SH2 domain

Gene Ontology (GO)

Displaying entries **21 - 30** of 31 in total

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GO Term
natural killer cell mediated cytotoxicity
regulation of B cell differentiation
platelet formation
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of mast cell activation involved in immune response
intracellular signal transduction
megakaryocyte development
negative regulation of peptidyl-tyrosine phosphorylation
negative regulation of inflammatory response to wounding

Displaying **all 7** entries
GO Term
nucleolus
cytoplasm
cell-cell junction
alpha-beta T cell receptor complex
cytosol
nucleoplasm
apical dendrite

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GO Term
cytokine receptor binding
protein kinase binding
cell adhesion molecule binding
SH3 domain binding
natural killer cell lectin-like receptor binding
phosphotyrosine residue binding
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
SH2 domain binding

Annotation information from UniProt.

Sequence

MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNITYPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
101			G41840AI	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 14** of 14 in total

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Pathway Name	Organism
Platelet sensitization by LDL	Mus musculus
Regulation of IFNA/IFNB signaling	Mus musculus
Regulation of KIT signaling	Mus musculus
Signaling by ALK	Mus musculus