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Metabotropic glutamate receptor 5

Summary

UniProt ID

P31424

Gene Symbol

Grm5
Gprc1e
Mglur5

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P31424

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Methylation
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 24 in total

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GO Term
synapse organization
cognition
modulation of chemical synaptic transmission
regulation of synaptic transmission, glutamatergic
regulation of long-term neuronal synaptic plasticity
positive regulation of long-term neuronal synaptic plasticity
regulation of DNA-templated transcription
desensitization of G protein-coupled receptor signaling pathway
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
phospholipase C-activating G protein-coupled receptor signaling pathway

Displaying **all 10** entries
GO Term
neuron projection
postsynaptic membrane
astrocyte projection
glutamatergic synapse
dendritic shaft
cytoplasm
plasma membrane
dendritic spine
Schaffer collateral - CA1 synapse
postsynaptic density membrane

Displaying entries **1 - 10** of 12 in total

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GO Term
protein tyrosine kinase activator activity
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
PDZ domain binding
A2A adenosine receptor binding
protein tyrosine kinase binding
identical protein binding
PLC activating G protein-coupled glutamate receptor activity
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
calmodulin binding
G protein-coupled receptor activity

Annotation information from UniProt.

Sequence

MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
88	N-linked (GlcNAc...) asparagine	UniProt
209	N-linked (GlcNAc...) asparagine	UniProt
377	N-linked (GlcNAc...) asparagine	UniProt
381	N-linked (GlcNAc...) asparagine	UniProt
444	N-linked (GlcNAc...) asparagine	UniProt
733	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Class C/3 (Metabotropic glutamate/pheromone receptors)	Rattus norvegicus
G alpha (q) signalling events	Rattus norvegicus
Neurexins and neuroligins	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements