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Dual specificity mitogen-activated protein kinase kinase 1

Summary

UniProt ID

P31938

Gene Symbol

Map2k1
Mek1
Prkmk1

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003563
GlyGen: P31938
PubChem: P31938
RaftProt: P31938

Annotation

Keyword

ATP-binding
Cytoskeleton
Direct protein sequencing
Membrane
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tyrosine-protein kinase

Gene Ontology (GO)

Displaying entries **1 - 10** of 54 in total

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GO Term
positive regulation of autophagy
negative regulation of cell population proliferation
positive regulation of gene expression
negative regulation of gene expression
Schwann cell development
keratinocyte differentiation
positive regulation of cell migration
negative regulation of homotypic cell-cell adhesion
myelination
positive regulation of muscle contraction

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GO Term
glutamatergic synapse
early endosome
late endosome
endoplasmic reticulum
Golgi apparatus
cytosol
perinuclear region of cytoplasm
nucleus
mitochondrion
plasma membrane

Displaying entries **1 - 10** of 13 in total

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GO Term
protein kinase binding
protein serine/threonine kinase activator activity
protein-containing complex binding
scaffold protein binding
protein serine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
small GTPase binding
mitogen-activated protein kinase kinase kinase binding
protein serine/threonine kinase activity

Annotation information from UniProt.

Sequence

MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
21			G40926MX	GlycoProtDB GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Frs2-mediated activation	Mus musculus
MAP2K and MAPK activation	Mus musculus
MAPK3 (ERK1) activation	Mus musculus
Negative feedback regulation of MAPK pathway	Mus musculus
RAF activation	Mus musculus
Signal transduction by L1	Mus musculus