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Amphiregulin

Summary

UniProt ID

P31955

Gene Symbol

Areg
Sdgf

Gene ID

11839

Organism

Mus musculus (house mouse)

External Links

PubChem: P31955
Re-Glyco: P31955

Annotation

Keyword

Cytokine
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
cell surface
extracellular space
nucleus
cytoplasm
membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 17 in total

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GO Term
ERBB2-EGFR signaling pathway
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
epithelial cell proliferation involved in mammary gland duct elongation
neuron projection development
response to estradiol
response to hydrogen peroxide
response to peptide hormone
negative regulation of osteoblast differentiation
response to glucocorticoid
mammary gland branching involved in thelarche

Displaying **all 5** entries
GO Term
epidermal growth factor receptor binding
receptor ligand activity
transmembrane receptor protein tyrosine kinase activator activity
cytokine activity
growth factor activity

Annotation information from UniProt.

Sequence

MRTPLLPLARSVLLLLVLGSGHYAAALELNDPSSGKGESLSGDHSAGGLELSVGREVSTISEMPSGSELSTGDYDYSEEYDNEPQISGYIIDDSVRVEQVIKPKKNKTEGEKSTEKPKRKKKGGKNGKGRRNKKKKNPCTAKFQNFCIHGECRYIENLEVVTCNCHQDYFGERCGEKSMKTHSEDDKDLSKIAVVAVTIFVSAIILAAIGIGIVITVHLWKRYFREYEGETEERRRLRQENGTVHAIA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
106	N-linked (GlcNAc...) asparagine			UniProt
241	N-linked (GlcNAc...) asparagine			UniProt

Feature

Domains & sites

PTM

ProtVista

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 14** of 14 in total

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Pathway Name	Organism
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mus musculus
RAF/MAP kinase cascade	Mus musculus
SHC1 events in EGFR signaling	Mus musculus
Signaling by EGFR	Mus musculus