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Type II inositol 1,4,5-trisphosphate 5-phosphatase

Summary

UniProt ID

P32019

Gene Symbol

INPP5B
OCRL2

Organism

Homo sapiens (human)

External Links

GlyGen: P32019
PubChem: P32019
The Human Metabolome Database: HMDBP01860
The O-GlcNAc Database: P32019

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Endosome
Golgi apparatus
Hydrolase
Lipid metabolism
Magnesium
Membrane
Metal-binding
Methylation
Prenylation
Reference proteome

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
in utero embryonic development
signal transduction
spermatogenesis
flagellated sperm motility
regulation of protein processing

Displaying **all 7** entries
GO Term
Golgi apparatus
plasma membrane
membrane
phagocytic vesicle membrane
early endosome membrane
cytosol
endoplasmic reticulum-Golgi intermediate compartment

Displaying **all 4** entries
GO Term
metal ion binding
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Annotation information from UniProt.

Sequence

MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRYPSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYSTYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Synthesis of IP2, IP, and Ins in the cytosol	Homo sapiens
Synthesis of IP3 and IP4 in the cytosol	Homo sapiens

Human Protein Atlas

ENSG00000204084

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **11 - 20** of 53 in total

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DO ID	Disease Name	Source
DOID:0110275	autosomal recessive limb-girdle muscular dystrophy type 2A	DisGeNET
DOID:0110276	autosomal recessive limb-girdle muscular dystrophy type 2B	DisGeNET
DOID:0110277	autosomal recessive limb-girdle muscular dystrophy type 2C	DisGeNET
DOID:0110278	autosomal recessive limb-girdle muscular dystrophy type 2D	DisGeNET
DOID:0110279	autosomal recessive limb-girdle muscular dystrophy type 2E	DisGeNET
DOID:0110280	autosomal recessive limb-girdle muscular dystrophy type 2F	DisGeNET
DOID:0110281	autosomal recessive limb-girdle muscular dystrophy type 2G	DisGeNET
DOID:0110282	autosomal recessive limb-girdle muscular dystrophy type 2H	DisGeNET
DOID:0110283	autosomal recessive limb-girdle muscular dystrophy type 2J	DisGeNET
DOID:0110284	autosomal recessive limb-girdle muscular dystrophy type 2L	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements