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Long-chain-fatty-acid--CoA ligase 1

Summary

UniProt ID

P33121

Gene Symbol

ACSL1
FACL1
FACL2
LACS
LACS1
LACS2

Organism

Homo sapiens (human)

External Links

GlyGen

P33121

PubChem

P33121

SwissLipids

The Human Metabolome Database

HMDBP00577

The O-GlcNAc Database

P33121

RaftProt

P33121

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Direct protein sequencing
Fatty acid metabolism
Glycoprotein
Ligase
Magnesium
Microsome
Mitochondrion outer membrane
Nitration
Peroxisome
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

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GO Term
lipid biosynthetic process
response to organic cyclic compound
fatty acid transport
long-chain fatty acid import into cell
response to nutrient
xenobiotic catabolic process
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
positive regulation of long-chain fatty acid import across plasma membrane
triglyceride biosynthetic process

Displaying **all 6** entries
GO Term
membrane
mitochondrion
endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrial outer membrane
peroxisomal membrane

Displaying **all 7** entries
GO Term
protein serine/threonine kinase activator activity
phytanate-CoA ligase activity
arachidonate-CoA ligase activity
long-chain fatty acid-CoA ligase activity
ATP binding
pristanate-CoA ligase activity
oleoyl-CoA ligase activity

Annotation information from UniProt.

Sequence

MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	GlyTouCan ID	Source
135	O-linked (GlcNAc) serine		UniProt GlyGen
246		G49108TO	GlyGen The O-GlcNAc Database
247		G49108TO	GlyGen The O-GlcNAc Database
382		G83460ZZ	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Linoleic acid (LA) metabolism	Homo sapiens
PPARA activates gene expression	Homo sapiens
Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens
alpha-linolenic acid (ALA) metabolism	Homo sapiens

Human Protein Atlas

ENSG00000151726

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **21 - 30** of 84 in total

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DO ID	Disease Name	Source
DOID:0110755	type 1 diabetes mellitus 18	DisGeNET
DOID:0110756	type 1 diabetes mellitus 19	DisGeNET
DOID:0110757	type 1 diabetes mellitus 20	DisGeNET
DOID:0110758	type 1 diabetes mellitus 21	DisGeNET
DOID:0110760	type 1 diabetes mellitus 23	DisGeNET
DOID:0110761	type 1 diabetes mellitus 24	DisGeNET
DOID:10952	nephritis	DisGeNET
DOID:11503	diabetic autonomic neuropathy	DisGeNET
DOID:11847	coronary thrombosis	DisGeNET
DOID:11984	hypertrophic cardiomyopathy	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Annotation

International Collaboration

Acknowledgements