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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Summary
- UniProt ID
- P33908
- Gene Symbol
-
- MAN1A1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011658
- GlyGen
- P33908
- PubChem
- P33908
- The Human Metabolome Database
- HMDBP00870
- RaftProt
- P33908
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Disulfide bond
- Glycoprotein
- Glycosidase
- Golgi apparatus
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| carbohydrate metabolic process |
| ERAD pathway |
| protein glycosylation |
| protein targeting to ER |
| mannose trimming involved in glycoprotein ERAD pathway |
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| membrane |
| cytoplasmic vesicle |
| extracellular exosome |
| cytosol |
| endoplasmic reticulum |
| endoplasmic reticulum-Golgi intermediate compartment |
| GO Term |
|---|
| calcium ion binding |
| mannosidase activity |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
Sequence
MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKDKKEVEIREE
Glycosylation Sites
G00912UN
G10488MI
G59626AS
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Intra-Golgi traffic | Homo sapiens |
| Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050570 | congenital disorder of glycosylation type I | |
| DOID:0080560 | congenital disorder of glycosylation Ih | |
| DOID:1612 | breast cancer | |
| DOID:162 | cancer | |
| DOID:1926 | Gaucher's disease | |
| DOID:2394 | ovarian cancer | |
| DOID:4001 | ovarian carcinoma | |
| DOID:5212 | congenital disorder of glycosylation | |
| DOID:526 | human immunodeficiency virus infectious disease | |
| DOID:635 | acquired immunodeficiency syndrome |
