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Cystic fibrosis transmembrane conductance regulator

Summary

UniProt ID

P34158

Gene Symbol

Cftr
Abcc7

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P34158

Annotation

Keyword

ATP-binding
Cell membrane
Chloride channel
Endoplasmic reticulum
Endosome
Glycoprotein
Isomerase
Nucleus
Palmitate
Phosphoprotein
Reference proteome
Repeat
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 37 in total

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GO Term
transepithelial chloride transport
cellular response to heat
response to estrogen
cholesterol biosynthetic process
water transport
multicellular organismal-level water homeostasis
establishment of localization in cell
amelogenesis
bicarbonate transport
lung development

Displaying entries **1 - 10** of 18 in total

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GO Term
basolateral plasma membrane
apical plasma membrane
early endosome membrane
chloride channel complex
cytosol
endoplasmic reticulum membrane
early endosome
cell surface
recycling endosome
nucleus

Displaying entries **1 - 10** of 14 in total

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GO Term
bicarbonate transmembrane transporter activity
enzyme binding
protein-folding chaperone binding
chloride channel inhibitor activity
PDZ domain binding
chloride transmembrane transporter activity
isomerase activity
ATP hydrolysis activity
ATPase-coupled transmembrane transporter activity
chloride channel activity

Annotation information from UniProt.

Sequence

MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDREQASKKKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEGLALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERLVITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFVVFLSVLPYTVINGIVLRKIFTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVLEYNLMFTGLVMENVTAFWEEGFQELLEKVQLNNDDRKTSNGENHLSFSHLCLVGNPVLKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKENIIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSILSSFSSVKKISIVQKTPLSIEGESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVLDLMTFTPSSVSSSLQRTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFDDMVKIPTVTTWNTYLRYFTLHRGLFAVLIWCVLVFLVEVAASLFVLWLLKNNPVNGGNNGTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHAPMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLAVFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHTANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSIDTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGEMVVKDLTVKYVDDGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGVSWNSMTLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGGYVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAMLDCQRFLVIEQGNVWQYESLQALLSEKSVFQRALSSSEKMKLFHGRHSSKQKPRTQITAVKEETEEEVQETRL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
889	N-linked (GlcNAc...) asparagine			UniProt
895	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
ABC-family proteins mediated transport	Rattus norvegicus
Aggrephagy	Rattus norvegicus
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
RHO GTPases regulate CFTR trafficking	Rattus norvegicus
RHOQ GTPase cycle	Rattus norvegicus
Ub-specific processing proteases	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Summary

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Annotation

International Collaboration

Acknowledgements