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Cystathionine beta-synthase

Summary

UniProt ID

P35520

Gene Symbol

Gene ID

875

Organism

Homo sapiens (human)

External Links

GlyGen: P35520
PubChem: P35520
The Human Metabolome Database: HMDBP00779
Re-Glyco: P35520

Annotation

Keyword

3D-structure
Allosteric enzyme
Alternative splicing
CBS domain
Cysteine biosynthesis
Cytoplasm
Disease variant
Heme
Isopeptide bond
Lyase
Nucleus
Phosphoprotein
Pyridoxal phosphate
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
cytosol
nucleus
cytoplasm

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 22 in total

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GO Term
negative regulation of apoptotic process
cysteine biosynthetic process from serine
L-serine catabolic process
regulation of nitric oxide mediated signal transduction
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
L-cysteine catabolic process
cerebellum morphogenesis
homocysteine catabolic process

Displaying entries **1 - 10** of 14 in total

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GO Term
metal ion binding
cystathionine beta-synthase activity
nitrite reductase (NO-forming) activity
carbon monoxide binding
nitric oxide binding
modified amino acid binding
S-adenosyl-L-methionine binding
oxygen binding
enzyme binding
heme binding

Annotation information from UniProt.

Sequence

MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
13				GlyGen
434			G43417UB	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Cysteine formation from homocysteine	Homo sapiens
Metabolism of ingested SeMet, Sec, MeSec into H2Se	Homo sapiens

Disease

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0080074	neural tube defect	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:9263	homocystinuria	Alliance of Genome Resources
DOID:9279	hyperhomocysteinemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements