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Insulin receptor substrate 1

Summary

UniProt ID

P35569

Gene Symbol

Irs-1
Irs1

Gene ID

16367

Organism

Mus musculus (house mouse)

External Links

GlyGen: P35569
PubChem: P35569
O-GlcNAcAtlas: P35569
Re-Glyco: P35569

Annotation

Keyword

3D-structure
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transducer
Ubl conjugation

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
cytosol
ciliary basal body
nucleus
cytoplasm
plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 13 in total

1

2

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GO Term
positive regulation of mesenchymal cell proliferation
regulation of gene expression
cell migration
insulin-like growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
cellular response to fatty acid
mammary gland development
insulin receptor signaling pathway
epithelial cell migration
positive regulation of epithelial cell migration

Displaying **all 8** entries
GO Term
transmembrane receptor protein tyrosine kinase adaptor activity
insulin-like growth factor receptor binding
phosphatidylinositol 3-kinase activator activity
insulin receptor binding
protein kinase binding
protein-macromolecule adaptor activity
SH2 domain binding
phosphatidylinositol 3-kinase binding

Annotation information from UniProt.

Sequence

MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIGPAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSASVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDLAKEHSQDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASISFQKQPEDRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites