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Insulin receptor substrate 1

Summary

UniProt ID

P35569

Gene Symbol

Irs1
Irs-1

Organism

Mus musculus (house mouse)

External Links

GlyGen: P35569
PubChem: P35569
O-GlcNAcAtlas: P35569

Annotation

Keyword

3D-structure
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transducer
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of mesenchymal cell proliferation
regulation of gene expression
cell migration
mammary gland development
positive regulation of phosphorylation
negative regulation of insulin secretion
positive regulation of glucagon secretion
negative regulation of somatostatin secretion
insulin receptor signaling pathway
epithelial cell migration

Displaying **all 6** entries
GO Term
cytosol
nucleus
cytoplasm
plasma membrane
insulin receptor complex
ciliary basal body

Displaying entries **1 - 10** of 11 in total

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GO Term
transmembrane receptor protein tyrosine kinase adaptor activity
insulin-like growth factor receptor binding
phosphatidylinositol 3-kinase activator activity
protein kinase C binding
insulin receptor binding
protein kinase binding
protein domain specific binding
protein-macromolecule adaptor activity
SH2 domain binding
protein-containing complex binding

Annotation information from UniProt.

Sequence

MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCPPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRIGPAPPGSATVCRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSASVTPQGATAEQATHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAGNTVPFGAGAAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDLAKEHSQDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASISFQKQPEDRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites