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Insulin receptor substrate 1

Summary

UniProt ID

P35570

Gene Symbol

Irs1
Irs-1

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P35570
PubChem: P35570
The O-GlcNAc Database: P35570
O-GlcNAcAtlas: P35570

Annotation

Keyword

3D-structure
Direct protein sequencing
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transducer
Ubl conjugation

Gene Ontology (GO)

Displaying entries **21 - 30** of 31 in total

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GO Term
positive regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
positive regulation of glucagon secretion
cellular response to fatty acid
negative regulation of somatostatin secretion
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
cellular response to brain-derived neurotrophic factor stimulus
response to caffeine
positive regulation of fatty acid beta-oxidation
phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying **all 8** entries
GO Term
nucleus
cytosol
caveola
ciliary basal body
cytoplasm
plasma membrane
insulin receptor complex
intracellular membrane-bounded organelle

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GO Term
phosphotyrosine residue binding
protein-macromolecule adaptor activity
transmembrane receptor protein tyrosine kinase adaptor activity
protein kinase C binding
insulin receptor binding
insulin-like growth factor receptor binding
signaling receptor complex adaptor activity
SH2 domain binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol 3-kinase activator activity

Annotation information from UniProt.

Sequence

MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRTKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPPGAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGAAPPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAANTVSFGAGAAGGGSGGGSEDVKRHSSASFENVWLRPGDLGGASKESAPGCGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPLGSNEGSSPRRSSEDLSTYASINFQKQPEDRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
914	G49108TO	GlyGen The O-GlcNAc Database
1009	G49108TO	GlyGen
1036	G49108TO	GlyGen The O-GlcNAc Database
1041	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 13 in total

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Pathway Name	Organism
IRS activation	Rattus norvegicus
IRS-mediated signalling	Rattus norvegicus
IRS-related events triggered by IGF1R	Rattus norvegicus
Interleukin-7 signaling	Rattus norvegicus
PI3K Cascade	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus
PI3K/AKT activation	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus
RAF/MAP kinase cascade	Rattus norvegicus
SOS-mediated signalling	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements