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Insulin receptor substrate 1

Summary

UniProt ID

P35570

Gene Symbol

Irs-1
Irs1

Gene ID

25467

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P35570
PubChem: P35570
The O-GlcNAc Database: P35570
O-GlcNAcAtlas: P35570
Re-Glyco: P35570

Annotation

Keyword

3D-structure
Direct protein sequencing
Phosphoprotein
Reference proteome
Repeat
S-nitrosylation
Transducer
Ubl conjugation

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
nucleus
cytoplasm
plasma membrane
intracellular membrane-bounded organelle
cytosol
insulin receptor complex
caveola
ciliary basal body

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 31 in total

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GO Term
positive regulation of glucagon secretion
negative regulation of somatostatin secretion
positive regulation of mesenchymal cell proliferation
regulation of gene expression
positive regulation of glucose metabolic process
cell migration
cytokine-mediated signaling pathway
mammary gland development
positive regulation of phosphorylation
positive regulation of glycogen biosynthetic process

Displaying entries **1 - 10** of 14 in total

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GO Term
phosphotyrosine residue binding
transmembrane receptor protein tyrosine kinase adaptor activity
insulin-like growth factor receptor binding
phosphatidylinositol 3-kinase activator activity
protein kinase C binding
insulin receptor binding
protein kinase binding
protein domain specific binding
protein-macromolecule adaptor activity
signaling adaptor activity

Annotation information from UniProt.

Sequence

MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAGGGCGGSCSGSSGVGEAGEDLSYDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEFRPRTKSQSSSSCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPNGHYILSRGGNGHRYIPGATMGTSPALTGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTPSQSSVVSIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDSSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSCSPDIGGGSCSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSVTHPHHHALQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQQQQQSSLHPPEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCLPQLHPAPREETGSEEYMNMDLGPGRRATWQESGGVELGRVGPAPPGAASICRPTRSVPNSRGDYMTMQIGCPRQSYVDTSPVAPVSYADMRTGIAAEKVSLPRTTGAAPPPSSTASASASVTPQGAAEQAAHSSLLGGPQGPGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAPTRAANTVSFGAGAAGGGSGGGSEDVKRHSSASFENVWLRPGDLGGASKESAPGCGAAGGLEKSLNYIDLDLVKDVKQHPQDCPSQQQSLPPPPPHQPLGSNEGSSPRRSSEDLSTYASINFQKQPEDRQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
914	G49108TO	GlyGen The O-GlcNAc Database
1009	G49108TO	GlyGen
1036	G49108TO	GlyGen The O-GlcNAc Database
1041	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 13** of 13 in total

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Pathway Name	Organism
Signal attenuation	Rattus norvegicus
Signaling by ALK	Rattus norvegicus
Signaling by LTK	Rattus norvegicus

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements