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Low-density lipoprotein receptor

Summary

UniProt ID

P35952

Gene Symbol

Ldlr

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P35952

Annotation

Keyword

Cell membrane
Cholesterol metabolism
Coated pit
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Golgi apparatus
LDL
Lipid transport
Lysosome
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **21 - 30** of 45 in total

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GO Term
positive regulation of triglyceride biosynthetic process
positive regulation of triglyceride catabolic process
regulation of phosphatidylcholine catabolic process
negative regulation of low-density lipoprotein particle clearance
phospholipid transport
cholesterol transport
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
receptor-mediated endocytosis involved in cholesterol transport
amyloid-beta clearance

Displaying entries **1 - 10** of 18 in total

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GO Term
recycling endosome membrane
PCSK9-LDLR complex
basolateral plasma membrane
apical part of cell
caveola
endosome
early endosome
late endosome
clathrin-coated pit
external side of plasma membrane

Displaying **all 10** entries
GO Term
apolipoprotein binding
molecular adaptor activity
lipoprotein particle binding
protease binding
calcium ion binding
very-low-density lipoprotein particle receptor activity
identical protein binding
amyloid-beta binding
low-density lipoprotein particle receptor activity
low-density lipoprotein particle binding

Annotation information from UniProt.

Sequence

MSTADLMLRWAIALLLAAAGVAAEDSCGKNEFQCRDGKCIVSKWVCDGSRECPDGSDESPETCMSVTCRSGEFSCGGRVSRCIPDSWRCDGRTDCENGSDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAATTCGPAHFRCNSSSCIPSLWACDGDRDCDDGSDEWPQNCGAEDTAAEVVSSPCSSLEFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSDEPIKECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLVDGHQCEDIDECQEPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVCKAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMDQGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIVLFHNVTQPRGVNWCEATVLPNGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDTVPTTQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHNEDPSATSTSRQPGDTPELSTVESVTVSSQVQGDMAGRGDEVQRHGVGFLSIFLPIALVALLVFGAILLWRNWRLRNINSINFDNPVYQKTTEDEIHICRSQDGYTYPSRQMVSLEDDVA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
97	N-linked (GlcNAc...) asparagine	UniProt
156	N-linked (GlcNAc...) asparagine	UniProt
273	N-linked (GlcNAc...) asparagine	UniProt
657	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Chylomicron clearance	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
LDL clearance	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements