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Receptor-type tyrosine-protein kinase FLT3

Summary

UniProt ID

P36888

Gene Symbol

FLT3
CD135
FLK2
STK1

Organism

Homo sapiens (human)

External Links

GlyGen: P36888
PubChem: P36888
The Human Metabolome Database: HMDBP01189

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Disease variant
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Host-virus interaction
Immunoglobulin domain
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **11 - 20** of 22 in total

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GO Term
dendritic cell differentiation
response to organonitrogen compound
animal organ regeneration
regulation of apoptotic process
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
protein autophosphorylation
positive regulation of MAP kinase activity
positive regulation of MAPK cascade

Displaying **all 5** entries
GO Term
plasma membrane
receptor complex
endoplasmic reticulum
endosome membrane
endoplasmic reticulum lumen

Displaying **all 10** entries
GO Term
vascular endothelial growth factor receptor activity
ATP binding
growth factor binding
protein self-association
phosphatidylinositol 3-kinase activator activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
cytokine receptor activity
protein-containing complex binding
nuclear glucocorticoid receptor binding

Annotation information from UniProt.

Sequence

MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
100	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
151	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
306	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
323	N-linked (GlcNAc...) asparagine	21389326	G80920RR	UniProt GlyGen
351	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
354	N-linked (GlcNAc...) asparagine	21389326		UniProt GlyGen
473				UniProt GlyGen
502				UniProt GlyGen
541	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **21 - 27** of 27 in total

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Pathway Name	Organism
ponatinib-resistant FLT3 mutants	Homo sapiens
quizartinib-resistant FLT3 mutants	Homo sapiens
semaxanib-resistant FLT3 mutants	Homo sapiens
sorafenib-resistant FLT3 mutants	Homo sapiens
sunitinib-resistant FLT3 mutants	Homo sapiens
tamatinib-resistant FLT3 mutants	Homo sapiens
tandutinib-resistant FLT3 mutants	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements