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Activin receptor type-1B

Summary

UniProt ID: P36896
Gene Symbol: ACVR1B ACVRLK4 ALK4
Gene ID: 91
Organism: Homo sapiens (human)

External Links

GlyGen: P36896
PubChem: P36896
The Human Metabolome Database: HMDBP01407
Re-Glyco: P36896

Annotation

Keyword: 3D-structure ATP-binding Alternative splicing Cell membrane Glycoprotein Magnesium Manganese Metal-binding Phosphoprotein Proteomics identification Receptor Reference proteome Serine/threonine-protein kinase Signal Transmembrane helix Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
G1/S transition of mitotic cell cycle	IDA	PMID
in utero embryonic development
hair follicle development
regulation of transcription, DNA-templated	IDA	PMID PMID
regulation of DNA-templated transcription	IDA	PMID PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway

nodal signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

peptidyl-threonine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

peptidyl-threonine phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-threonine modification [inference]

peptidyl-threonine phosphorylation

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

system development [inference]

nervous system development

animal gross anatomical part developmental process [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of erythrocyte differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of trophoblast cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

positive regulation of trophoblast cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of trophoblast cell migration

positive regulation of reproductive process [inference]

positive regulation of trophoblast cell migration

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of developmental process [inference]

negative regulation of cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of erythrocyte differentiation [inference]

positive regulation of erythrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

positive regulation of trophoblast cell migration

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of erythrocyte differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway

nodal signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of activin receptor signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of cell differentiation [inference]

negative regulation of cell differentiation

positive regulation of cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of erythrocyte differentiation [inference]

positive regulation of erythrocyte differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of activin receptor signaling pathway

positive regulation of cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of trophoblast cell migration [inference]

positive regulation of trophoblast cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of trophoblast cell migration

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification

positive regulation of multicellular organismal process [inference]

positive regulation of trophoblast cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

positive regulation of myeloid cell differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of erythrocyte differentiation [inference]

positive regulation of erythrocyte differentiation

regulation of reproductive process [inference]

positive regulation of reproductive process [inference]

positive regulation of trophoblast cell migration

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome Reactome
plasma membrane	IDA	PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF
cell surface	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

plasma membrane signaling receptor complex [inference]

activin receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

activin receptor complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

activin receptor complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
protein serine/threonine kinase activity	EXP	PMID
protein serine/threonine kinase activity	TAS	Reactome
protein serine/threonine kinase activity	IDA	PMID PMID
protein serine/threonine kinase activity	IEA	GO_REF
transmembrane receptor protein serine/threonine kinase activity	NAS	PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

binding [inference]

protein binding [inference]

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

inhibin binding

SMAD binding

I-SMAD binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

activin binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity

activin receptor activity

activin receptor activity, type I

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
43	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Regulation of signaling by NODAL	Homo sapiens
Signaling by Activin	Homo sapiens
Signaling by NODAL	Homo sapiens

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:1790	malignant mesothelioma	Alliance of Genome Resources
DOID:5409	lung small cell carcinoma	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements