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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
TGF-beta receptor type-2
Summary
- UniProt ID
- P37173
- Gene Symbol
-
- TGFBR2
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011669
- GlyConnect
- GlyGen
- P37173
- PubChem
- P37173
- The Human Metabolome Database
- HMDBP01237
- RaftProt
- P37173
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Aortic aneurysm
- Apoptosis
- Cell membrane
- Craniosynostosis
- Differentiation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Growth regulation
- Hereditary nonpolyposis colorectal cancer
- Magnesium
- Manganese
- Metal-binding
- Phosphoprotein
- Receptor
- Reference proteome
- Secreted
- Serine/threonine-protein kinase
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| miRNA transport |
| GO Term |
|---|
| activin binding |
| transforming growth factor beta binding |
| molecular adaptor activity |
| kinase activator activity |
Sequence
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 31 |
|
|||
| 39 |
|
|||
| 70 | N-linked (GlcNAc...) asparagine |
|
||
| 94 | N-linked (GlcNAc...) asparagine | |||
| 154 | N-linked (GlcNAc...) asparagine |
|
||
| 266 |
|
|||
| 564 |
|
G57321FI
G57888GL
G22310AV
G80920RR
G62765YT
G62461SM
G55412XP
G38663NM
G13694XX
G37881RL
G56784JY
G11629QQ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Downregulation of TGF-beta receptor signaling | Homo sapiens |
| SMAD2/3 Phosphorylation Motif Mutants in Cancer | Homo sapiens |
| TGF-beta receptor signaling activates SMADs | Homo sapiens |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | Homo sapiens |
| TGFBR1 KD Mutants in Cancer | Homo sapiens |
| TGFBR1 LBD Mutants in Cancer | Homo sapiens |
| TGFBR2 Kinase Domain Mutants in Cancer | Homo sapiens |
| TGFBR2 MSI Frameshift Mutants in Cancer | Homo sapiens |
| TGFBR3 regulates TGF-beta signaling | Homo sapiens |
| UCH proteinases | Homo sapiens |
